Abstract
Pancreatic cancer is the fourth leading cause of cancer death for both men and women in the United States. It is a highly fatal disease with a 5-year survival rate of approximately 6%. Obesity, in addition to cigarette smoking and diabetes, is one of the few modifiable risk factors that have been associated with increased risk of pancreatic cancer. Obesity has also been associated with an early onset and reduced survival of pancreatic cancer. Insulin resistance and inflammation are two most anticipated biological mechanisms that link obesity and pancreatic cancer. Because of the high prevalence of overweight or obesity in the U.S. population, a better understanding of the complex association between obesity and pancreatic cancer may provide opportunities for the development of novel strategies in prevention and treatment of this deadly disease. The current epidemiological evidence and potential biological mechanisms involved in the obesity-pancreatic cancer association are reviewed.
Original language | English (US) |
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Title of host publication | Energy Balance and Gastrointestinal Cancer |
Publisher | Springer US |
Pages | 93-109 |
Number of pages | 17 |
ISBN (Electronic) | 9781461423676 |
ISBN (Print) | 9781461423669 |
DOIs | |
State | Published - Jan 1 2012 |
ASJC Scopus subject areas
- General Medicine