OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus

Thea Kristin Våtsveen, Erming Tian, Stine H. Kresse, Leonardo A. Meza-Zepeda, Ana Gabrea, Oleg Glebov, Hong Yan Dai, Anders Sundan, W. Michael Kuehl, Magne Børset

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Multiple myeloma can be classified into hyperdiploid (HRD) (with 48-74 chromosomes) and non-hyperdiploid tumors (usually with immunoglobulin heavy chain translocations). The OH-2 human myeloma cell line (HMCL) retains the same HRD genotype as the primary tumor, with extra copies of chromosomes 3, 7, 15, 19, and 21. Both OH-2 and primary cells have a complex secondary translocation in which the IGK 3′ enhancer is inserted between MYC and MAFB, resulting in dysregulation of both oncogenes. OH-2 provides a unique example of an HMCL and the corresponding primary tumor that are shown to share the same HRD genotype.

Original languageEnglish (US)
Pages (from-to)1670-1677
Number of pages8
JournalLeukemia Research
Volume33
Issue number12
DOIs
StatePublished - Dec 1 2009

Fingerprint

Polyploidy
Cell Line
Genotype
Neoplasms
Immunoglobulin Heavy Chains
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 7
Multiple Myeloma
Oncogenes
Chromosomes
hydroxide ion

Keywords

  • Array CGH
  • FISH
  • Hyperdiploid
  • IGK
  • MAFB
  • MYC

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus. / Våtsveen, Thea Kristin; Tian, Erming; Kresse, Stine H.; Meza-Zepeda, Leonardo A.; Gabrea, Ana; Glebov, Oleg; Dai, Hong Yan; Sundan, Anders; Kuehl, W. Michael; Børset, Magne.

In: Leukemia Research, Vol. 33, No. 12, 01.12.2009, p. 1670-1677.

Research output: Contribution to journalArticle

Våtsveen, Thea Kristin ; Tian, Erming ; Kresse, Stine H. ; Meza-Zepeda, Leonardo A. ; Gabrea, Ana ; Glebov, Oleg ; Dai, Hong Yan ; Sundan, Anders ; Kuehl, W. Michael ; Børset, Magne. / OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus. In: Leukemia Research. 2009 ; Vol. 33, No. 12. pp. 1670-1677.
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abstract = "Multiple myeloma can be classified into hyperdiploid (HRD) (with 48-74 chromosomes) and non-hyperdiploid tumors (usually with immunoglobulin heavy chain translocations). The OH-2 human myeloma cell line (HMCL) retains the same HRD genotype as the primary tumor, with extra copies of chromosomes 3, 7, 15, 19, and 21. Both OH-2 and primary cells have a complex secondary translocation in which the IGK 3′ enhancer is inserted between MYC and MAFB, resulting in dysregulation of both oncogenes. OH-2 provides a unique example of an HMCL and the corresponding primary tumor that are shown to share the same HRD genotype.",
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AU - Tian, Erming

AU - Kresse, Stine H.

AU - Meza-Zepeda, Leonardo A.

AU - Gabrea, Ana

AU - Glebov, Oleg

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AU - Sundan, Anders

AU - Kuehl, W. Michael

AU - Børset, Magne

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