TY - GEN
T1 - On stability of molecular therapeutic agents for noninvasive photoacoustic and ultrasound image-guided photothermal therapy
AU - Chen, Yun Sheng
AU - Kruizinga, Pieter
AU - Joshi, Pratixa P.
AU - Kim, Seungsoo
AU - Homan, Kimberly
AU - Sokolov, Konstantin
AU - Frey, Wolfgang
AU - Emelianov, Stanislav
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - Image-guided molecular photothermal therapy using targeted gold nanoparticles acting as photoabsorbers can be used to noninvasively treat various medical conditions including cancer. Among different types of gold nanoparticles, gold nanorods are an attractive candidate for both photothermal therapy and photoacoustic imaging due to their high and tunable optical absorption cross-section. However, nanorods are not thermodynamically stable; under laser exposure, the nanorods can easily transform to spheres, thus changing their desired optical properties. In this study, gold-silica coreshell nanorods were prepared by coating silica directly onto the surface of PEGylated gold nanorods using a modified Stöber method. The nanorods were exposed to 800 nm wavelength, 7 ns pulses of light at a 10 Hz pulse repetition rate. For different fluences ranging from 0 to 8 mJ/cm2, the optical extinction spectrum was measured before and after the exposure to investigate their photothermal stability. Finally, the effectiveness of gold-silica core-shell nanoparticles as a photoacoustic contrast agent and photothermal nanoabsorber was tested using inclusion-embedded phantoms and a combined ultrasound and photoacoustic imaging system. The results of our study suggest that gold-silica core-shell nanorods are excellent candidates for image-guided molecular photothermal therapy.
AB - Image-guided molecular photothermal therapy using targeted gold nanoparticles acting as photoabsorbers can be used to noninvasively treat various medical conditions including cancer. Among different types of gold nanoparticles, gold nanorods are an attractive candidate for both photothermal therapy and photoacoustic imaging due to their high and tunable optical absorption cross-section. However, nanorods are not thermodynamically stable; under laser exposure, the nanorods can easily transform to spheres, thus changing their desired optical properties. In this study, gold-silica coreshell nanorods were prepared by coating silica directly onto the surface of PEGylated gold nanorods using a modified Stöber method. The nanorods were exposed to 800 nm wavelength, 7 ns pulses of light at a 10 Hz pulse repetition rate. For different fluences ranging from 0 to 8 mJ/cm2, the optical extinction spectrum was measured before and after the exposure to investigate their photothermal stability. Finally, the effectiveness of gold-silica core-shell nanoparticles as a photoacoustic contrast agent and photothermal nanoabsorber was tested using inclusion-embedded phantoms and a combined ultrasound and photoacoustic imaging system. The results of our study suggest that gold-silica core-shell nanorods are excellent candidates for image-guided molecular photothermal therapy.
KW - Cancer therapy
KW - Gold-silica core-shell nanorods
KW - Photoacoustic imaging
KW - Photothermal therapy
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=77951550141&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951550141&partnerID=8YFLogxK
U2 - 10.1117/12.842906
DO - 10.1117/12.842906
M3 - Conference contribution
AN - SCOPUS:77951550141
SN - 9780819479600
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photons Plus Ultrasound
T2 - Photons Plus Ultrasound: Imaging and Sensing 2010
Y2 - 24 January 2010 through 26 January 2010
ER -