On the role of acylation of transmembrane proteins

Diana Morozova, Matthias Weiss

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Acylation is a frequent means to ensure membrane association of a variety of soluble proteins in living cells. However, many transmembrane proteins are palmitoylated, indicating that this posttranslational modification may also serve as a means to regulate protein trafficking. Based on coarse-grained membrane simulations, we find that protein acylation significantly alters the tilting of transmembrane proteins with respect to the bilayer normal. In addition, the proteins' partitioning behavior and cluster formation ability due to hydrophobic mismatching is strongly altered. Based on our results, we propose that acylation is a potent means to regulate the trafficking of transmembrane proteins along the early secretory pathway.

Original languageEnglish (US)
Pages (from-to)800-804
Number of pages5
JournalBiophysical journal
Volume98
Issue number5
DOIs
StatePublished - Mar 3 2010

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Acylation
Protein Transport
Proteins
Membranes
Secretory Pathway
Post Translational Protein Processing

ASJC Scopus subject areas

  • Biophysics

Cite this

On the role of acylation of transmembrane proteins. / Morozova, Diana; Weiss, Matthias.

In: Biophysical journal, Vol. 98, No. 5, 03.03.2010, p. 800-804.

Research output: Contribution to journalArticle

Morozova, Diana ; Weiss, Matthias. / On the role of acylation of transmembrane proteins. In: Biophysical journal. 2010 ; Vol. 98, No. 5. pp. 800-804.
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