Oncogenic roles of carbonic anhydrase IX in human nasopharyngeal carcinoma

Yi Sang, Li Wang, Jian Jun Tang, Mei Fang Zhang, Meng Xia Zhang, Xia Liu, Ru Hua Zhang, Tie-Bang Kang, Ming-Yuan Chen

    Research output: Contribution to journalArticle

    8 Scopus citations

    Abstract

    Carbonic anhydrase IX (CA IX), a hypoxia-inducible protein in tumors, has been shown to be valuable for the prognosis of nasopharyngeal carcinoma (NPC). However, the function and mechanism of CA IX has been not explored in NPC. Here, we found that CA IX was detected at higher levels in NPC cells and tissues than their corresponding partners. Furthermore, the cell growth, migration and invasion in vitro were altered with shRNA or overexpression of CA IX in NPC cells. More importantly, the metastatic ability of NPC cells stably expressing CA IX was signiicantly enhanced using the hepatic metastasis model of nude mice in vivo. Finally, the mTOR pathway was indicated to be involved in such effects of CA IX on NPC. This is the irst evidence that CA IX may promote the NPC metastasis to potentially be a therapeutic target for NPC, and that the inhibitory molecules of CA IX and/or the mTOR pathway alone or combination with both may be worth to have a clinical trial for the patients with NPC.

    Original languageEnglish (US)
    Pages (from-to)2942-2949
    Number of pages8
    JournalInternational journal of clinical and experimental pathology
    Volume7
    Issue number6
    StatePublished - Jan 1 2014

    Keywords

    • CA IX
    • Growth
    • Metastasis
    • NPC
    • mTOR

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine
    • Histology

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    Sang, Y., Wang, L., Tang, J. J., Zhang, M. F., Zhang, M. X., Liu, X., Zhang, R. H., Kang, T-B., & Chen, M-Y. (2014). Oncogenic roles of carbonic anhydrase IX in human nasopharyngeal carcinoma. International journal of clinical and experimental pathology, 7(6), 2942-2949.