Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients

Maher Karam-Hage, Kirk J. Brower

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Alcohol-dependent outpatients with persisting insomnia were treated with either gabapentin or trazodone. Patients were assessed at baseline and after 4-6 weeks on medication using the Sleep Problems Questionnaire (SPQ). Of 55 cases initially treated, 9% dropped out due to morning drowsiness. Of the remaining 50 cases, 34 were treated with gabapentin (mean dose± SD=888±418mg) at bedtime and 16 were treated with trazodone (105±57mg) at bedtime. Both groups improved significantly on the SPQ but the gabapentin group improved significantly more than the trazodone group. Controlled studies are warranted to replicate these findings.

Original languageEnglish (US)
Pages (from-to)542-544
Number of pages3
JournalPsychiatry and Clinical Neurosciences
Volume57
Issue number5
DOIs
StatePublished - Oct 2003
Externally publishedYes

Keywords

  • Alcoholism
  • Drug therapy
  • Gabapentin
  • Insomnia
  • Trazodone

ASJC Scopus subject areas

  • General Neuroscience
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Fingerprint

Dive into the research topics of 'Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients'. Together they form a unique fingerprint.

Cite this