Optical sectioning wide-field microscopy for imaging oral cancer

M. M. Abd-El-Barr, E. R. Hsu, E. V. Anslyn, M. R. Descour, R. Lotan, A. M. Gillenwater, R. R. Richards-Kortum

Research output: Contribution to journalConference articlepeer-review


We describe the use of an optical sectioning wide-field microscope with an exogenous dye in order to improve the visualization of early oral cancer detection. We show positive results in imaging and optically sectioning turbid tissue phantoms stained with Acridine Orange, a non-specific fluorescent DNA dye. This optical technique, if coupled with appropriate contrast agents could improve both the visualization and specificity of epithelial cancer detection.

Original languageEnglish (US)
Pages (from-to)2306-2307
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
StatePublished - 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002


  • Microscopy
  • Optical sectioning
  • Tumor detection

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics


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