Optical sectioning wide-field microscopy for imaging oral cancer

M. M. Abd-El-Barr; E. R. Hsu; E. V. Anslyn; M. R. Descour; R. Lotan; A. M. Gillenwater; R. R. Richards-Kortum

Optical sectioning wide-field microscopy for imaging oral cancer

M. M. Abd-El-Barr, E. R. Hsu, E. V. Anslyn, M. R. Descour, R. Lotan, A. M. Gillenwater, R. R. Richards-Kortum

Head & Neck Surgery

Research output: Contribution to journal › Conference article › peer-review

Abstract

We describe the use of an optical sectioning wide-field microscope with an exogenous dye in order to improve the visualization of early oral cancer detection. We show positive results in imaging and optically sectioning turbid tissue phantoms stained with Acridine Orange, a non-specific fluorescent DNA dye. This optical technique, if coupled with appropriate contrast agents could improve both the visualization and specificity of epithelial cancer detection.

Original language	English (US)
Pages (from-to)	2306-2307
Number of pages	2
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	3
State	Published - 2002
Event	Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: Oct 23 2002 → Oct 26 2002

Keywords

Microscopy
Optical sectioning
Tumor detection

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Cite this

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title = "Optical sectioning wide-field microscopy for imaging oral cancer",

abstract = "We describe the use of an optical sectioning wide-field microscope with an exogenous dye in order to improve the visualization of early oral cancer detection. We show positive results in imaging and optically sectioning turbid tissue phantoms stained with Acridine Orange, a non-specific fluorescent DNA dye. This optical technique, if coupled with appropriate contrast agents could improve both the visualization and specificity of epithelial cancer detection.",

keywords = "Microscopy, Optical sectioning, Tumor detection",

author = "Abd-El-Barr, {M. M.} and Hsu, {E. R.} and Anslyn, {E. V.} and Descour, {M. R.} and R. Lotan and Gillenwater, {A. M.} and Richards-Kortum, {R. R.}",

note = "Copyright: Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.; Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) ; Conference date: 23-10-2002 Through 26-10-2002",

year = "2002",

language = "English (US)",

volume = "3",

pages = "2306--2307",

journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

issn = "0589-1019",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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TY - JOUR

T1 - Optical sectioning wide-field microscopy for imaging oral cancer

AU - Abd-El-Barr, M. M.

AU - Hsu, E. R.

AU - Anslyn, E. V.

AU - Descour, M. R.

AU - Lotan, R.

AU - Gillenwater, A. M.

AU - Richards-Kortum, R. R.

PY - 2002

Y1 - 2002

N2 - We describe the use of an optical sectioning wide-field microscope with an exogenous dye in order to improve the visualization of early oral cancer detection. We show positive results in imaging and optically sectioning turbid tissue phantoms stained with Acridine Orange, a non-specific fluorescent DNA dye. This optical technique, if coupled with appropriate contrast agents could improve both the visualization and specificity of epithelial cancer detection.

AB - We describe the use of an optical sectioning wide-field microscope with an exogenous dye in order to improve the visualization of early oral cancer detection. We show positive results in imaging and optically sectioning turbid tissue phantoms stained with Acridine Orange, a non-specific fluorescent DNA dye. This optical technique, if coupled with appropriate contrast agents could improve both the visualization and specificity of epithelial cancer detection.

KW - Microscopy

KW - Optical sectioning

KW - Tumor detection

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UR - http://www.scopus.com/inward/citedby.url?scp=0036916060&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0036916060

SN - 0589-1019

VL - 3

SP - 2306

EP - 2307

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

T2 - Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS)

Y2 - 23 October 2002 through 26 October 2002

ER -

Optical sectioning wide-field microscopy for imaging oral cancer

Abstract

Keywords

ASJC Scopus subject areas

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