TY - JOUR
T1 - Optical tracking of acoustic radiation force impulse-induced dynamics in a tissue-mimicking phantom
AU - Bouchard, Richard R.
AU - Palmeri, Mark L.
AU - Pinton, Gianmarco F.
AU - Trahey, Gregg E.
AU - Streeter, Jason E.
AU - Dayton, Paul A.
N1 - Funding Information:
This work was supported in part by a National Science Foundation Graduate Research Fellowship. The authors thank Gijs van Soest, Carl Herickhoff, and Michael Giacomelli for their insight and Ned Rouze for intensity measurement assistance.
PY - 2009
Y1 - 2009
N2 - Optical tracking was utilized to investigate the acoustic radiation force impulse (ARFI)-induced response, generated by a 5-MHz piston transducer, in a translucent tissue-mimicking phantom. Suspended 10-μm microspheres were tracked axially and laterally at multiple locations throughout the field of view of an optical microscope with 0.5-μm displacement resolution, in both dimensions, and at frame rates of up to 36 kHz. Induced dynamics were successfully captured before, during, and after the ARFI excitation at depths of up to 4.8 mm from the phantom's proximal boundary. Results are presented for tracked axial and lateral displacements resulting from on-axis and off-axis (i.e., shear wave) acquisitions; these results are compared to matched finite element method modeling and independent ultrasonically based empirical results and yielded reasonable agreement in most cases. A shear wave reflection, generated by the proximal boundary, consistently produced an artifact in tracked displacement data later in time (i.e., after the initial ARFI-induced displacement peak). This tracking method provides high-frame-rate, two-dimensional tracking data and thus could prove useful in the investigation of complex ARFI-induced dynamics in controlled experimental settings.
AB - Optical tracking was utilized to investigate the acoustic radiation force impulse (ARFI)-induced response, generated by a 5-MHz piston transducer, in a translucent tissue-mimicking phantom. Suspended 10-μm microspheres were tracked axially and laterally at multiple locations throughout the field of view of an optical microscope with 0.5-μm displacement resolution, in both dimensions, and at frame rates of up to 36 kHz. Induced dynamics were successfully captured before, during, and after the ARFI excitation at depths of up to 4.8 mm from the phantom's proximal boundary. Results are presented for tracked axial and lateral displacements resulting from on-axis and off-axis (i.e., shear wave) acquisitions; these results are compared to matched finite element method modeling and independent ultrasonically based empirical results and yielded reasonable agreement in most cases. A shear wave reflection, generated by the proximal boundary, consistently produced an artifact in tracked displacement data later in time (i.e., after the initial ARFI-induced displacement peak). This tracking method provides high-frame-rate, two-dimensional tracking data and thus could prove useful in the investigation of complex ARFI-induced dynamics in controlled experimental settings.
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U2 - 10.1121/1.3238235
DO - 10.1121/1.3238235
M3 - Article
C2 - 19894849
AN - SCOPUS:70449371963
SN - 0001-4966
VL - 126
SP - 2733
EP - 2745
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
IS - 5
ER -