Outcome of postradiation osteosarcoma does not correlate with chemotherapy response

Postradiation osteosarcoma is a rare tumor with a historically poor prognosis. Recent reports concerning the prognosis of the disease have been conflicting. We ascertained the long-term outcome of patients with this disease treated in the era of contemporary chemotherapy. Twenty-seven patients diagnosed with postradiation osteosarcoma and treated with chemotherapy and surgical resection from 1980-2003 were identified. Demographics, anatomic location, stage, chemo- therapy, necrosis rate, recurrence and metastatic rates were recorded; Kaplan-Meier survival rates were estimated. The median age was 54 years (range, 12-86 years). Nineteen patients were female and eight patients were male. Median followup was 39.2 months (range, 0-218 months). Twenty- two patients received induction chemotherapy for a mean of four cycles (range, 2-6 cycles). Mean tumor necrosis was63.5%. Seven patients had ≥90% necrosis; four of these patients died of their disease. The mean survival was 23 months, and the 5-year disease free survival estimate was27.2%. Histologic response to chemotherapy did not correlate with survival. Patients who had a latency of greater than 10 years after radiation had a better prognosis. Unlike conventional osteosarcoma, response to chemotherapy (necrosis) did not have prognostic significance. Current chemo- therapy regimens fail to impact survival in postradiation osteosarcoma.