TY - JOUR
T1 - Ovarian cancer metastasis
T2 - Looking beyond the surface
AU - Bayraktar, Emine
AU - Chen, Sisy
AU - Corvigno, Sara
AU - Liu, Jinsong
AU - Sood, Anil K
N1 - Publisher Copyright:
© 2024 Elsevier Inc.
PY - 2024/10/14
Y1 - 2024/10/14
N2 - Historically, ovarian cancer (OC) was thought to metastasize by surface-to-surface spread, but recent developments have yielded a new understanding of the paths of metastatic spread. Given the histologic and molecular heterogeneity of OC, we will focus on high-grade serous carcinoma (HGSC). Here, we provide a critical and more holistic view of the evidence supporting various routes of metastasis, including peritoneal, hematogenous, lymphatic, and nerve related. Understanding the underlying mechanisms is necessary to improve treatment strategies for this challenging disease.
AB - Historically, ovarian cancer (OC) was thought to metastasize by surface-to-surface spread, but recent developments have yielded a new understanding of the paths of metastatic spread. Given the histologic and molecular heterogeneity of OC, we will focus on high-grade serous carcinoma (HGSC). Here, we provide a critical and more holistic view of the evidence supporting various routes of metastasis, including peritoneal, hematogenous, lymphatic, and nerve related. Understanding the underlying mechanisms is necessary to improve treatment strategies for this challenging disease.
UR - http://www.scopus.com/inward/record.url?scp=85206596931&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85206596931&partnerID=8YFLogxK
U2 - 10.1016/j.ccell.2024.08.016
DO - 10.1016/j.ccell.2024.08.016
M3 - Comment/debate
C2 - 39270645
AN - SCOPUS:85206596931
SN - 1535-6108
VL - 42
SP - 1631
EP - 1636
JO - Cancer cell
JF - Cancer cell
IS - 10
ER -