TY - JOUR
T1 - OVCA1
T2 - Tumor suppressor gene
AU - Chen, Chun Ming
AU - Behringer, Richard R.
N1 - Funding Information:
We thank Dr Randy Johnson for helpful comments on the manuscript. Figure illustration by Ting-Hsuan Chen (undergraduate program in Faculty of Life Sciences, National Yang-Ming University, Taipei, Taiwan). C-MC gratefully acknowledges the Connie and Jim Walters Fellowship in Sarcoma Research. Supported by National Institutes of Health grant HD30284 to RRB and National Science Council, Taiwan, NSC 93-2752-B-010-004-PAE to C-MC under Dr. Ming-Ta Hsu; National Yang-Ming University, Taipei, Taiwan.
PY - 2005/2
Y1 - 2005/2
N2 - OVCA1, also known as DPH2L1, is a tumor suppressor gene associated with ovarian carcinoma and other tumors. Ovca1 homozygous mutant mice die at birth with developmental delay and cell-autonomous proliferation defects. Ovca1 heterozygous mutant mice are tumor-prone but rarely develop ovarian tumors. OVCA1 appears to be the homolog of yeast DPH2, which participates in the first biosynthetic step of diphthamide, by modification of histidine on translation elongation factor 2 (EF-2). Yeast dph2 mutants are resistant to diphtheria toxin, which catalyses ADP ribosylation of EF-2 at diphthamide. Thus, there appears to be growing evidence implicating alterations in protein translation with tumorigenesis.
AB - OVCA1, also known as DPH2L1, is a tumor suppressor gene associated with ovarian carcinoma and other tumors. Ovca1 homozygous mutant mice die at birth with developmental delay and cell-autonomous proliferation defects. Ovca1 heterozygous mutant mice are tumor-prone but rarely develop ovarian tumors. OVCA1 appears to be the homolog of yeast DPH2, which participates in the first biosynthetic step of diphthamide, by modification of histidine on translation elongation factor 2 (EF-2). Yeast dph2 mutants are resistant to diphtheria toxin, which catalyses ADP ribosylation of EF-2 at diphthamide. Thus, there appears to be growing evidence implicating alterations in protein translation with tumorigenesis.
UR - http://www.scopus.com/inward/record.url?scp=12344267743&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12344267743&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2004.12.006
DO - 10.1016/j.gde.2004.12.006
M3 - Review article
C2 - 15661533
AN - SCOPUS:12344267743
SN - 0959-437X
VL - 15
SP - 49
EP - 54
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 1
ER -