TY - JOUR
T1 - Overall survival in older patients with cancer
AU - Edwards, Beatrice J.
AU - Zhang, Xiaotao
AU - Sun, Ming
AU - Song, Juhee
AU - Khalil, Peter
AU - Karuturi, Meghan Sri
AU - Pang, Linda
AU - Geng, Yunlong
AU - Dinney, Colin P.
AU - Valero, Vicente
AU - Champlin, Richard E.
AU - Tripathy, Debasish
N1 - Publisher Copyright:
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2020. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Objectives A growing number of patients with cancer are older adults. We sought to identify the predictors for overall survival (OS) in older adults with solid tumour and haematological malignancies between January 2013 and December 2016. Methods Retrospective cohort study. A comprehensive geriatric assessment was performed, with a median follow-up of 12.8 months. Analysis: univariate and multivariate Cox proportional hazards regression analysis. Results In this study, among the 455 patients with last follow-up date or date of death, 152 (33.4%) died during the follow-up. The median follow-up is 12.8 months (range 0.2-51.1 months) and the median OS is 20.5 months (range 0.3-44.5 months). Among all older patients with cancer, predictors of OS included male gender, cancer stage, malnutrition, history of smoking, heavy alcohol use, frailty, weight loss, major depression, low body weight and nursing home residence. Traditional performance scores (Eastern Cooperative Oncology Group (ECOG) and Karnofsky Performance Scale (KPS)) were predictors of OS. Independent predictors included age >85 years and haematological malignancies. Among solid tumours (n=311) in addition to the above predictors, comorbidity, gait speed and vitamin D deficiency were associated with OS. Conclusions We identified specific geriatric factors associated with OS in older patients with cancer, and comparable in predictive ability to traditional performance scores such as KPS and ECOG. Prospective studies will be necessary to confirm our findings.
AB - Objectives A growing number of patients with cancer are older adults. We sought to identify the predictors for overall survival (OS) in older adults with solid tumour and haematological malignancies between January 2013 and December 2016. Methods Retrospective cohort study. A comprehensive geriatric assessment was performed, with a median follow-up of 12.8 months. Analysis: univariate and multivariate Cox proportional hazards regression analysis. Results In this study, among the 455 patients with last follow-up date or date of death, 152 (33.4%) died during the follow-up. The median follow-up is 12.8 months (range 0.2-51.1 months) and the median OS is 20.5 months (range 0.3-44.5 months). Among all older patients with cancer, predictors of OS included male gender, cancer stage, malnutrition, history of smoking, heavy alcohol use, frailty, weight loss, major depression, low body weight and nursing home residence. Traditional performance scores (Eastern Cooperative Oncology Group (ECOG) and Karnofsky Performance Scale (KPS)) were predictors of OS. Independent predictors included age >85 years and haematological malignancies. Among solid tumours (n=311) in addition to the above predictors, comorbidity, gait speed and vitamin D deficiency were associated with OS. Conclusions We identified specific geriatric factors associated with OS in older patients with cancer, and comparable in predictive ability to traditional performance scores such as KPS and ECOG. Prospective studies will be necessary to confirm our findings.
KW - cognitive impairment
KW - depression
KW - functional impairment
KW - older adults with cancer
KW - social support
KW - survival
UR - http://www.scopus.com/inward/record.url?scp=85053847001&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053847001&partnerID=8YFLogxK
U2 - 10.1136/bmjspcare-2018-001516
DO - 10.1136/bmjspcare-2018-001516
M3 - Article
C2 - 30244203
AN - SCOPUS:85053847001
SN - 2045-435X
VL - 10
SP - 25
EP - 35
JO - BMJ Supportive and Palliative Care
JF - BMJ Supportive and Palliative Care
IS - 1
ER -