Overexpression and cytoplasmic localisation of Sam68 correlates with tumour progression and poor prognosis in patients with clinically N0 oral tongue cancer

S. W. Chen, Q. Zhang, A. K. Yang, Z. Li, Y. Zhong, H. Li, Y. Zeng, S. M. Zhuang, L. P. Wang, L. B. Song, Z. M. Guo, M. Song

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6 Citations (Scopus)

Abstract

Src-associated protein in mitosis (Sam68, 68 kDa), the substrate of Src in mitosis, has been reported to correlate with the progression and outcome of many tumour types. In this study, we report Sam68 overexpression in clinically N0 (cN0) oral tongue cancer and its correlation with the clinicopathologic characteristics and prognosis of patients. Analysis of oral tongue cancer cell lines and cancerous tissues revealed that Sam68 was up-regulated at both the messenger ribonucleic acid and the protein level. Immunohistochemical study of Sam68 protein expression and localisation in 181 cN0 oral tongue cancer samples confirmed the results, which showed significantly shorter overall and disease-free survival after surgery in cases with higher Sam68 expression (p = 0.009 and p = 0.002, respectively) and cytoplasmic localisation of Sam68 (p < 0.001 and p = 0.007, respectively). Sam68 overexpression significantly correlated with pathologic stage (p = 0.001), T classification (p = 0.001), N classification (p = 0.026), nodal status (p = 0.021) and recurrence (p = 0.002). Cytoplasmic localisation of Sam68 was significantly associated with pathologic stage (p = 0.004), N classification (p = 0.002), nodal status (p = 0.001) and recurrence (p = 0.007). Multivariate analysis indicated that Sam68 overexpression and cytoplasmic localisation were independent predictors for poor survival of cN0 oral tongue cancer patients. Our results indicate that Sam68 could represent a novel and useful prognostic factor for cN0 oral tongue cancer. Overexpression and cytoplasmic localisation of Sam68 expression portend a poor prognosis in cN0 oral tongue cancer patients.

Original languageEnglish (US)
Article number62
JournalHead and Neck Oncology
Volume4
Issue number2
StatePublished - Sep 9 2012

Fingerprint

Tongue Neoplasms
Mouth Neoplasms
Neoplasms
Mitosis
Recurrence
Proteins
Disease-Free Survival
Multivariate Analysis
RNA
Cell Line
Survival

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Oncology

Cite this

Overexpression and cytoplasmic localisation of Sam68 correlates with tumour progression and poor prognosis in patients with clinically N0 oral tongue cancer. / Chen, S. W.; Zhang, Q.; Yang, A. K.; Li, Z.; Zhong, Y.; Li, H.; Zeng, Y.; Zhuang, S. M.; Wang, L. P.; Song, L. B.; Guo, Z. M.; Song, M.

In: Head and Neck Oncology, Vol. 4, No. 2, 62, 09.09.2012.

Research output: Contribution to journalArticle

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abstract = "Src-associated protein in mitosis (Sam68, 68 kDa), the substrate of Src in mitosis, has been reported to correlate with the progression and outcome of many tumour types. In this study, we report Sam68 overexpression in clinically N0 (cN0) oral tongue cancer and its correlation with the clinicopathologic characteristics and prognosis of patients. Analysis of oral tongue cancer cell lines and cancerous tissues revealed that Sam68 was up-regulated at both the messenger ribonucleic acid and the protein level. Immunohistochemical study of Sam68 protein expression and localisation in 181 cN0 oral tongue cancer samples confirmed the results, which showed significantly shorter overall and disease-free survival after surgery in cases with higher Sam68 expression (p = 0.009 and p = 0.002, respectively) and cytoplasmic localisation of Sam68 (p < 0.001 and p = 0.007, respectively). Sam68 overexpression significantly correlated with pathologic stage (p = 0.001), T classification (p = 0.001), N classification (p = 0.026), nodal status (p = 0.021) and recurrence (p = 0.002). Cytoplasmic localisation of Sam68 was significantly associated with pathologic stage (p = 0.004), N classification (p = 0.002), nodal status (p = 0.001) and recurrence (p = 0.007). Multivariate analysis indicated that Sam68 overexpression and cytoplasmic localisation were independent predictors for poor survival of cN0 oral tongue cancer patients. Our results indicate that Sam68 could represent a novel and useful prognostic factor for cN0 oral tongue cancer. Overexpression and cytoplasmic localisation of Sam68 expression portend a poor prognosis in cN0 oral tongue cancer patients.",
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AU - Zhong, Y.

AU - Li, H.

AU - Zeng, Y.

AU - Zhuang, S. M.

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AU - Guo, Z. M.

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