Oxidative burden and antioxidant defense system in polymorphonuclear leukocytes of human lung diseases

Rashmi N. Sharma, A. Bhardwaj, D. Behera, K. L. Khanduja

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Superoxide anion (O 2. -) and hydrogen peroxide (H 2O 2) production was significantly higher in blood neutrophils (PMNs) of patients with lung cancer and non-malignant lung diseases when compared to the controls (p<0.001). Superoxide dismutase (SOD) activity was significantly decreased in PMNs of patients with lung cancer (p<0.001). Similarly, catalase and glutathione peroxidase (GPx) activities were lower in PMNs of lung cancer patients as compared to non-malignant lung diseases and controls. There was an increase in HMP shunt activity as measured by rate of formation of 14CO 2 from [1- 14C]-glucose in PMNs of lung cancer patients. Modifications in the antioxidant defense system in PMNs of malignant and non-malignant lung diseases, the changes being more in the malignancy are indicated.

Original languageEnglish (US)
Pages (from-to)124-129
Number of pages6
JournalIndian Journal of Biochemistry and Biophysics
Volume39
Issue number2
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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