Abstract
Superoxide anion (O 2. -) and hydrogen peroxide (H 2O 2) production was significantly higher in blood neutrophils (PMNs) of patients with lung cancer and non-malignant lung diseases when compared to the controls (p<0.001). Superoxide dismutase (SOD) activity was significantly decreased in PMNs of patients with lung cancer (p<0.001). Similarly, catalase and glutathione peroxidase (GPx) activities were lower in PMNs of lung cancer patients as compared to non-malignant lung diseases and controls. There was an increase in HMP shunt activity as measured by rate of formation of 14CO 2 from [1- 14C]-glucose in PMNs of lung cancer patients. Modifications in the antioxidant defense system in PMNs of malignant and non-malignant lung diseases, the changes being more in the malignancy are indicated.
Original language | English (US) |
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Pages (from-to) | 124-129 |
Number of pages | 6 |
Journal | Indian Journal of Biochemistry and Biophysics |
Volume | 39 |
Issue number | 2 |
State | Published - 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry