Paeonol promoted 2-aminofluorene and p-aminobenzoic acid acetylations by mononuclear leucocytes from Sprague-Dawley rats

H. L. Chang, C. F. Hung, C. C. Yen, W. C. Chang, J. G. Chung

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Following exposure of rats to the arylamine carcinogen 2-aminofluorene, DNA-carcinogen adducts were found in the target tissues of the liver and bladder, and also in circulating leucocytes. This work investigated how paeonol affects arylamine (2-aminofluorene and p-aminobenzoic acid) acetylations in rat leucocytes. Evidence is presented showing that rat mononuclear leucocytes are capable of acetylating 2-aminofluorene and p-aminobenzoic acid. Paeonol promoted 2-aminofluorene and p-aminobenzoic acid acetylation. Cultured lymphocytes produced about twice as much N-acetyl-2-aminofluorene from 2-aminofluorene and 2.2-fold as much N-acetyl-p-aminobenzoic acid from p-aminobenzoic acid as monocytes. After cotreatment with paeonol, the lymphocyte and monocyte cultures indicated that paeonol did increase 2-aminofluorene and p-aminobenzoic acid acetylations.

Original languageEnglish (US)
Pages (from-to)149-158
Number of pages10
JournalCytobios
Volume2000
Issue number404
StatePublished - Dec 1 2000

Fingerprint

p-aminobenzoic acid
4-Aminobenzoic Acid
Mononuclear Leukocytes
acetylation
Acetylation
mononuclear leukocytes
Sprague Dawley Rats
acid
rats
Carcinogens
carcinogen
carcinogens
Monocytes
Leukocytes
monocytes
Lymphocytes
leukocytes
2-Acetylaminofluorene
lymphocytes
bladder

Keywords

  • 2-aminofluorene
  • Ellagic acid
  • N-acetyltransferase
  • p-aminobenzoic acid

ASJC Scopus subject areas

  • Aquatic Science
  • Cell Biology

Cite this

Paeonol promoted 2-aminofluorene and p-aminobenzoic acid acetylations by mononuclear leucocytes from Sprague-Dawley rats. / Chang, H. L.; Hung, C. F.; Yen, C. C.; Chang, W. C.; Chung, J. G.

In: Cytobios, Vol. 2000, No. 404, 01.12.2000, p. 149-158.

Research output: Contribution to journalArticle

Chang, H. L. ; Hung, C. F. ; Yen, C. C. ; Chang, W. C. ; Chung, J. G. / Paeonol promoted 2-aminofluorene and p-aminobenzoic acid acetylations by mononuclear leucocytes from Sprague-Dawley rats. In: Cytobios. 2000 ; Vol. 2000, No. 404. pp. 149-158.
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AU - Chang, H. L.

AU - Hung, C. F.

AU - Yen, C. C.

AU - Chang, W. C.

AU - Chung, J. G.

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N2 - Following exposure of rats to the arylamine carcinogen 2-aminofluorene, DNA-carcinogen adducts were found in the target tissues of the liver and bladder, and also in circulating leucocytes. This work investigated how paeonol affects arylamine (2-aminofluorene and p-aminobenzoic acid) acetylations in rat leucocytes. Evidence is presented showing that rat mononuclear leucocytes are capable of acetylating 2-aminofluorene and p-aminobenzoic acid. Paeonol promoted 2-aminofluorene and p-aminobenzoic acid acetylation. Cultured lymphocytes produced about twice as much N-acetyl-2-aminofluorene from 2-aminofluorene and 2.2-fold as much N-acetyl-p-aminobenzoic acid from p-aminobenzoic acid as monocytes. After cotreatment with paeonol, the lymphocyte and monocyte cultures indicated that paeonol did increase 2-aminofluorene and p-aminobenzoic acid acetylations.

AB - Following exposure of rats to the arylamine carcinogen 2-aminofluorene, DNA-carcinogen adducts were found in the target tissues of the liver and bladder, and also in circulating leucocytes. This work investigated how paeonol affects arylamine (2-aminofluorene and p-aminobenzoic acid) acetylations in rat leucocytes. Evidence is presented showing that rat mononuclear leucocytes are capable of acetylating 2-aminofluorene and p-aminobenzoic acid. Paeonol promoted 2-aminofluorene and p-aminobenzoic acid acetylation. Cultured lymphocytes produced about twice as much N-acetyl-2-aminofluorene from 2-aminofluorene and 2.2-fold as much N-acetyl-p-aminobenzoic acid from p-aminobenzoic acid as monocytes. After cotreatment with paeonol, the lymphocyte and monocyte cultures indicated that paeonol did increase 2-aminofluorene and p-aminobenzoic acid acetylations.

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