Pancreatic acinar-to-ductal metaplasia and pancreatic cancer

Liang Wang, Dacheng Xie, Daoyan Wei

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Acinar-to-ductal metaplasia (ADM) of the pancreas is a process that pancreatic acinar cells differentiate into ductal-like cells with ductal cell traits. The metaplasia of pancreatic acinar cells manifests their ability to adapt to the genetic and environmental pressure they encounter. However, with oncogenic genetic insults and/or sustained environmental stress, ADM may lead to pancreatic intraepithelial neoplasia (PanIN), which is a common precancerous lesion that precedes pancreatic cancer. Understanding the intermediate states of ADM and important molecules that regulate ADM formation may help the development of novel preventive strategies that could be translated to the clinic to benefit the people with high risk of pancreatic cancer. Mouse model is widely used in both in vivo and ex vivo studies of ADM. In this chapter, we describe detailed protocols of injury models of the adult mouse pancreas that can function as a tool to study mechanisms of ADM formation.

LanguageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages299-308
Number of pages10
DOIs
StatePublished - Jan 1 2019

Publication series

NameMethods in Molecular Biology
Volume1882
ISSN (Print)1064-3745

Fingerprint

Metaplasia
Pancreatic Neoplasms
Acinar Cells
Pancreas
Pressure
Wounds and Injuries
Neoplasms

Keywords

  • Acinar-to-ductal metaplasia
  • Explant culture
  • Pancreatic cancer
  • Pancreatic ductal ligation
  • Pancreatitis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Wang, L., Xie, D., & Wei, D. (2019). Pancreatic acinar-to-ductal metaplasia and pancreatic cancer. In Methods in Molecular Biology (pp. 299-308). (Methods in Molecular Biology; Vol. 1882). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-8879-2_26

Pancreatic acinar-to-ductal metaplasia and pancreatic cancer. / Wang, Liang; Xie, Dacheng; Wei, Daoyan.

Methods in Molecular Biology. Humana Press Inc., 2019. p. 299-308 (Methods in Molecular Biology; Vol. 1882).

Research output: Chapter in Book/Report/Conference proceedingChapter

Wang, L, Xie, D & Wei, D 2019, Pancreatic acinar-to-ductal metaplasia and pancreatic cancer. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1882, Humana Press Inc., pp. 299-308. https://doi.org/10.1007/978-1-4939-8879-2_26
Wang L, Xie D, Wei D. Pancreatic acinar-to-ductal metaplasia and pancreatic cancer. In Methods in Molecular Biology. Humana Press Inc. 2019. p. 299-308. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-8879-2_26
Wang, Liang ; Xie, Dacheng ; Wei, Daoyan. / Pancreatic acinar-to-ductal metaplasia and pancreatic cancer. Methods in Molecular Biology. Humana Press Inc., 2019. pp. 299-308 (Methods in Molecular Biology).
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