Abstract
Traditionally, pancreatic ductal adenocarcinoma with regional vascular involvement was thought to represent unresectable disease and was associated with disease progression and death within 1 year of diagnosis. Recent evidence demonstrates that pancreaticoduodenectomy with vascular resection and reconstruction can be safely performed in select patients with 5-year survival rates as high as 20%. In order to safely treat and to optimize survival in these complex patients, it is essential to accurately identify vascular involvement preoperatively, to utilize a multidisciplinary treatment approach, and to emphasize meticulous surgical technique with awareness of the critical margins of resection.
Original language | English (US) |
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Pages (from-to) | 919-929 |
Number of pages | 11 |
Journal | Expert review of anticancer therapy |
Volume | 14 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2014 |
Keywords
- celiac axis
- hepatic artery
- multimodality therapy
- pancreatic adenocarcinoma
- portal vein
- superior mesenteric artery
- superior mesenteric vein
- vascular involvement
- vascular resection
ASJC Scopus subject areas
- Oncology
- Pharmacology (medical)