TY - JOUR
T1 - Papillary squamous cell carcinomas of the upper aerodigestive tract
T2 - A clinicopathologic and molecular study
AU - Suarez, Patricia A.
AU - Adler-Storthz, Karen
AU - Luna, Mario A.
AU - El-Naggar, Adel K.
AU - Abdul-Karim, Fadi W.
AU - Batsakis, John G.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2000/7
Y1 - 2000/7
N2 - Background. The limited studies and the small number of published cases of papillary squamous cell carcinoma have precluded accurate assessment of the biologic characteristics of this lesion. Methods. Thirty-eight of the carcinomas were studied. In-situ hybridization and polymerase chain reaction were performed to detect human papilloma virus (HPV) and p53 expression. Results. HPV was found in 4 of 14 assessable carcinomas by in-situ hybridization and in 5 of 14 by polymerase chain reaction. The most frequently identified HPVs were HPVs in 6/11 and 16/18 patients. In general, a reciprocal relationship was found between p53 and HPV prevalence. The most lethal site for this tumor was the sinonasal tract, whereas patients with papillary squamous cell carcinomas of the larynx had the best outlook. Eleven of 25 (44%) assessable patients died of disease (mean time interval, 2 year). Conclusions. Papillary squamous cell carcinoma of the upper aerodigestive tract is a distinct variant of squamous cell carcinoma. As such and because of its putative association with HPV, papillary squamous cell carcinoma could be an informative model for defining how viral oncogenes cooperate with other factors in genomic instability, carcinogenesis, and tumor development. (C) 2000 John Wiley and Sons, Inc.
AB - Background. The limited studies and the small number of published cases of papillary squamous cell carcinoma have precluded accurate assessment of the biologic characteristics of this lesion. Methods. Thirty-eight of the carcinomas were studied. In-situ hybridization and polymerase chain reaction were performed to detect human papilloma virus (HPV) and p53 expression. Results. HPV was found in 4 of 14 assessable carcinomas by in-situ hybridization and in 5 of 14 by polymerase chain reaction. The most frequently identified HPVs were HPVs in 6/11 and 16/18 patients. In general, a reciprocal relationship was found between p53 and HPV prevalence. The most lethal site for this tumor was the sinonasal tract, whereas patients with papillary squamous cell carcinomas of the larynx had the best outlook. Eleven of 25 (44%) assessable patients died of disease (mean time interval, 2 year). Conclusions. Papillary squamous cell carcinoma of the upper aerodigestive tract is a distinct variant of squamous cell carcinoma. As such and because of its putative association with HPV, papillary squamous cell carcinoma could be an informative model for defining how viral oncogenes cooperate with other factors in genomic instability, carcinogenesis, and tumor development. (C) 2000 John Wiley and Sons, Inc.
KW - Clinicopathologic study
KW - Molecular study
KW - Papillary squamous cell carcinomas
KW - Upper aerodigestive tract
UR - http://www.scopus.com/inward/record.url?scp=0034125982&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034125982&partnerID=8YFLogxK
U2 - 10.1002/1097-0347(200007)22:4<360::AID-HED8>3.0.CO;2-W
DO - 10.1002/1097-0347(200007)22:4<360::AID-HED8>3.0.CO;2-W
M3 - Article
C2 - 10862019
AN - SCOPUS:0034125982
SN - 1043-3074
VL - 22
SP - 360
EP - 368
JO - Head and Neck
JF - Head and Neck
IS - 4
ER -