Papillary Thyroid Cancer—Aggressive Variants and Impact on Management: A Narrative Review

Andrés Coca-Pelaz; Jatin P. Shah; Juan C. Hernandez-Prera; Ronald A. Ghossein; Juan P. Rodrigo; Dana M. Hartl; Kerry D. Olsen; Ashok R. Shaha; Mark Zafereo; Carlos Suarez; Iain J. Nixon; Gregory W. Randolph; Antti A. Mäkitie; Luiz P. Kowalski; Vincent Vander Poorten; Alvaro Sanabria; Orlando Guntinas-Lichius; Ricard Simo; Peter Zbären; Peter Angelos; Avi Khafif; Alessandra Rinaldo; Alfio Ferlito

doi:10.1007/s12325-020-01391-1

Papillary Thyroid Cancer—Aggressive Variants and Impact on Management: A Narrative Review

Andrés Coca-Pelaz, Jatin P. Shah, Juan C. Hernandez-Prera, Ronald A. Ghossein, Juan P. Rodrigo, Dana M. Hartl, Kerry D. Olsen, Ashok R. Shaha, Mark Zafereo, Carlos Suarez, Iain J. Nixon, Gregory W. Randolph, Antti A. Mäkitie, Luiz P. Kowalski, Vincent Vander Poorten, Alvaro Sanabria, Orlando Guntinas-Lichius, Ricard Simo, Peter Zbären, Peter AngelosAvi Khafif, Alessandra Rinaldo, Alfio Ferlito

Head & Neck Surgery

Research output: Contribution to journal › Review article › peer-review

109 Scopus citations

Abstract

Introduction: Aggressive variants of papillary thyroid cancer (PTC) have been described with increasing frequency. These variants include diffuse sclerosing variant, tall cell variant, columnar cell variant, solid variant, and hobnail variant. Methods: We have performed a review of the more aggressive variants of PTC with respect to main characteristics, histological and molecular features, and the consequences that the knowledge of these variants should have in the treatment of the patients. Results: At the present time, we do not know the prognostic value of these aggressive PTC variants. The extent of the surgical treatment and adjuvant therapy necessary should be decided on the basis of the extent of the tumor at presentation and the opinion of experienced clinicians. Conclusion: These aggressive variants should be known by clinicians, to avoid underdiagnosis, and treated according to the latest recommendations in the literature.

Original language	English (US)
Pages (from-to)	3112-3128
Number of pages	17
Journal	Advances in Therapy
Volume	37
Issue number	7
DOIs	https://doi.org/10.1007/s12325-020-01391-1
State	Published - Jul 1 2020

Keywords

Aggressive variants papillary thyroid cancer
Columnar cell variant
Diffuse sclerosis variant
Hobnail variant
Solid variant
Tall cell variant

ASJC Scopus subject areas

Pharmacology (medical)

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10.1007/s12325-020-01391-1

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Coca-Pelaz, A., Shah, J. P., Hernandez-Prera, J. C., Ghossein, R. A., Rodrigo, J. P., Hartl, D. M., Olsen, K. D., Shaha, A. R., Zafereo, M., Suarez, C., Nixon, I. J., Randolph, G. W., Mäkitie, A. A., Kowalski, L. P., Vander Poorten, V., Sanabria, A., Guntinas-Lichius, O., Simo, R., Zbären, P., ... Ferlito, A. (2020). Papillary Thyroid Cancer—Aggressive Variants and Impact on Management: A Narrative Review. Advances in Therapy, 37(7), 3112-3128. https://doi.org/10.1007/s12325-020-01391-1

Coca-Pelaz, A, Shah, JP, Hernandez-Prera, JC, Ghossein, RA, Rodrigo, JP, Hartl, DM, Olsen, KD, Shaha, AR, Zafereo, M, Suarez, C, Nixon, IJ, Randolph, GW, Mäkitie, AA, Kowalski, LP, Vander Poorten, V, Sanabria, A, Guntinas-Lichius, O, Simo, R, Zbären, P, Angelos, P, Khafif, A, Rinaldo, A & Ferlito, A 2020, 'Papillary Thyroid Cancer—Aggressive Variants and Impact on Management: A Narrative Review', Advances in Therapy, vol. 37, no. 7, pp. 3112-3128. https://doi.org/10.1007/s12325-020-01391-1

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abstract = "Introduction: Aggressive variants of papillary thyroid cancer (PTC) have been described with increasing frequency. These variants include diffuse sclerosing variant, tall cell variant, columnar cell variant, solid variant, and hobnail variant. Methods: We have performed a review of the more aggressive variants of PTC with respect to main characteristics, histological and molecular features, and the consequences that the knowledge of these variants should have in the treatment of the patients. Results: At the present time, we do not know the prognostic value of these aggressive PTC variants. The extent of the surgical treatment and adjuvant therapy necessary should be decided on the basis of the extent of the tumor at presentation and the opinion of experienced clinicians. Conclusion: These aggressive variants should be known by clinicians, to avoid underdiagnosis, and treated according to the latest recommendations in the literature.",

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T1 - Papillary Thyroid Cancer—Aggressive Variants and Impact on Management

T2 - A Narrative Review

AU - Coca-Pelaz, Andrés

AU - Shah, Jatin P.

AU - Hernandez-Prera, Juan C.

AU - Ghossein, Ronald A.

AU - Rodrigo, Juan P.

AU - Hartl, Dana M.

AU - Olsen, Kerry D.

AU - Shaha, Ashok R.

AU - Zafereo, Mark

AU - Suarez, Carlos

AU - Nixon, Iain J.

AU - Randolph, Gregory W.

AU - Mäkitie, Antti A.

AU - Kowalski, Luiz P.

AU - Vander Poorten, Vincent

AU - Sanabria, Alvaro

AU - Guntinas-Lichius, Orlando

AU - Simo, Ricard

AU - Zbären, Peter

AU - Angelos, Peter

AU - Khafif, Avi

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Introduction: Aggressive variants of papillary thyroid cancer (PTC) have been described with increasing frequency. These variants include diffuse sclerosing variant, tall cell variant, columnar cell variant, solid variant, and hobnail variant. Methods: We have performed a review of the more aggressive variants of PTC with respect to main characteristics, histological and molecular features, and the consequences that the knowledge of these variants should have in the treatment of the patients. Results: At the present time, we do not know the prognostic value of these aggressive PTC variants. The extent of the surgical treatment and adjuvant therapy necessary should be decided on the basis of the extent of the tumor at presentation and the opinion of experienced clinicians. Conclusion: These aggressive variants should be known by clinicians, to avoid underdiagnosis, and treated according to the latest recommendations in the literature.

AB - Introduction: Aggressive variants of papillary thyroid cancer (PTC) have been described with increasing frequency. These variants include diffuse sclerosing variant, tall cell variant, columnar cell variant, solid variant, and hobnail variant. Methods: We have performed a review of the more aggressive variants of PTC with respect to main characteristics, histological and molecular features, and the consequences that the knowledge of these variants should have in the treatment of the patients. Results: At the present time, we do not know the prognostic value of these aggressive PTC variants. The extent of the surgical treatment and adjuvant therapy necessary should be decided on the basis of the extent of the tumor at presentation and the opinion of experienced clinicians. Conclusion: These aggressive variants should be known by clinicians, to avoid underdiagnosis, and treated according to the latest recommendations in the literature.

KW - Aggressive variants papillary thyroid cancer

KW - Columnar cell variant

KW - Diffuse sclerosis variant

KW - Hobnail variant

KW - Solid variant

KW - Tall cell variant

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Papillary Thyroid Cancer—Aggressive Variants and Impact on Management: A Narrative Review

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Keywords

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