Pathological significance and mechanism of advanced glycation end-products

Mian En Sun, Guan Hua Du

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Advanced Glycation End-products (AGEs) are the products of non-enzymatic glycation protein. It has been demonstrated that AGEs are closely correlated to a variety of diseases such as diabetes, vascular complications, aging and renal diseases, AGEs play important roles in the development of these diseases. They can effect the function of cells and tissues directly, and also mediate pathological reactions through binding with special receptors. The present paper reviews the procedures of AGEs production, action mechanism and pathology of AGEs.

Original languageEnglish (US)
Pages (from-to)246-249
Number of pages4
JournalChinese Pharmacological Bulletin
Volume18
Issue number3
StatePublished - 2002
Externally publishedYes

Keywords

  • AGEs
  • Aging
  • Diabetes
  • Maillard reaction

ASJC Scopus subject areas

  • Pharmacology

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