Pathology Characterization and Detection of Human Papillomavirus Type 16 in Rectal Squamous Cell Carcinomas

Anna E. Coghill; Andrew M. Bellizzi; Charles F. Lynch; Meredith S. Shiels; Freda R. Selk; Maura Gillison; Brenda Y. Hernandez; Owen T.M. Chan; Eric A. Engels

doi:10.1016/j.cgh.2018.11.006

Pathology Characterization and Detection of Human Papillomavirus Type 16 in Rectal Squamous Cell Carcinomas

Anna E. Coghill, Andrew M. Bellizzi, Charles F. Lynch, Meredith S. Shiels, Freda R. Selk, Maura Gillison, Brenda Y. Hernandez, Owen T.M. Chan, Eric A. Engels

Thoracic Head & Neck Medical Oncology

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Rectal squamous cell carcinoma (SCC) is a rare tumor with unresolved etiology. Human immunodeficiency virus–infected individuals and solid organ transplant recipients experience >30-fold and approximately 3-fold elevated rates of rectal SCC, respectively, suggesting immunosuppression plays a role.¹ Human immunodeficiency virus–infected homosexual men have >60-fold higher rates of rectal SCC, similar to anal SCC. These patterns, which differ from the more common rectal adenocarcinoma (AdCA), raise the possibility of shared etiology between rectal and anal SCC, with human papillomavirus type 16 (HPV16) being a likely candidate.²

Original language	English (US)
Pages (from-to)	2129-2131
Number of pages	3
Journal	Clinical Gastroenterology and Hepatology
Volume	17
Issue number	10
DOIs	https://doi.org/10.1016/j.cgh.2018.11.006
State	Published - Sep 2019

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1016/j.cgh.2018.11.006

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@article{eb44744e55c64561bd77da1a751d2b1d,

title = "Pathology Characterization and Detection of Human Papillomavirus Type 16 in Rectal Squamous Cell Carcinomas",

abstract = "Rectal squamous cell carcinoma (SCC) is a rare tumor with unresolved etiology. Human immunodeficiency virus–infected individuals and solid organ transplant recipients experience >30-fold and approximately 3-fold elevated rates of rectal SCC, respectively, suggesting immunosuppression plays a role.1 Human immunodeficiency virus–infected homosexual men have >60-fold higher rates of rectal SCC, similar to anal SCC. These patterns, which differ from the more common rectal adenocarcinoma (AdCA), raise the possibility of shared etiology between rectal and anal SCC, with human papillomavirus type 16 (HPV16) being a likely candidate.2",

author = "Coghill, {Anna E.} and Bellizzi, {Andrew M.} and Lynch, {Charles F.} and Shiels, {Meredith S.} and Selk, {Freda R.} and Maura Gillison and Hernandez, {Brenda Y.} and Chan, {Owen T.M.} and Engels, {Eric A.}",

note = "Publisher Copyright: {\textcopyright} 2019 AGA Institute",

year = "2019",

month = sep,

doi = "10.1016/j.cgh.2018.11.006",

language = "English (US)",

volume = "17",

pages = "2129--2131",

journal = "Clinical Gastroenterology and Hepatology",

issn = "1542-3565",

publisher = "W.B. Saunders Ltd",

number = "10",

}

TY - JOUR

T1 - Pathology Characterization and Detection of Human Papillomavirus Type 16 in Rectal Squamous Cell Carcinomas

AU - Coghill, Anna E.

AU - Bellizzi, Andrew M.

AU - Lynch, Charles F.

AU - Shiels, Meredith S.

AU - Selk, Freda R.

AU - Gillison, Maura

AU - Hernandez, Brenda Y.

AU - Chan, Owen T.M.

AU - Engels, Eric A.

PY - 2019/9

Y1 - 2019/9

N2 - Rectal squamous cell carcinoma (SCC) is a rare tumor with unresolved etiology. Human immunodeficiency virus–infected individuals and solid organ transplant recipients experience >30-fold and approximately 3-fold elevated rates of rectal SCC, respectively, suggesting immunosuppression plays a role.1 Human immunodeficiency virus–infected homosexual men have >60-fold higher rates of rectal SCC, similar to anal SCC. These patterns, which differ from the more common rectal adenocarcinoma (AdCA), raise the possibility of shared etiology between rectal and anal SCC, with human papillomavirus type 16 (HPV16) being a likely candidate.2

AB - Rectal squamous cell carcinoma (SCC) is a rare tumor with unresolved etiology. Human immunodeficiency virus–infected individuals and solid organ transplant recipients experience >30-fold and approximately 3-fold elevated rates of rectal SCC, respectively, suggesting immunosuppression plays a role.1 Human immunodeficiency virus–infected homosexual men have >60-fold higher rates of rectal SCC, similar to anal SCC. These patterns, which differ from the more common rectal adenocarcinoma (AdCA), raise the possibility of shared etiology between rectal and anal SCC, with human papillomavirus type 16 (HPV16) being a likely candidate.2

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U2 - 10.1016/j.cgh.2018.11.006

DO - 10.1016/j.cgh.2018.11.006

M3 - Short survey

C2 - 30448596

AN - SCOPUS:85070921468

SN - 1542-3565

VL - 17

SP - 2129

EP - 2131

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

IS - 10

ER -

Pathology Characterization and Detection of Human Papillomavirus Type 16 in Rectal Squamous Cell Carcinomas

Abstract

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