Pathways: Strategies for susceptibility genes in SLE

James Michael Kelley, Jeffrey C. Edberg, Robert P. Kimberly

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder marked by an inappropriate immune response to nuclear antigens. Recent whole genome association and more focused studies have revealed numerous genes implicated in this disease process, including ITGAM, Fc gamma receptors, complement components, C-reactive protein, and others. One common feature of these molecules is their involvement in the immune opsonin pathway and in phagocytic clearing of nuclear antigens and apoptotic debris, which provide excessive exposure of lupus-related antigens to immune cells. Analysis of gene-gene interactions in the opsonin pathway and its relationship to SLE may provide a system-based approach to identify additional candidate genes associated with disease able to account for a larger part of lupus susceptibility.

Original languageEnglish (US)
Pages (from-to)473-476
Number of pages4
JournalAutoimmunity Reviews
Volume9
Issue number7
DOIs
StatePublished - May 1 2010

Keywords

  • Genetic association
  • Opsonin
  • Pathway
  • SLE

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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