Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response

Wenxiang Hu; Chunjie Jiang; Dongyin Guan; Pieterjan Dierickx; Rong Zhang; Arden Moscati; Girish N. Nadkarni; David J. Steger; Ruth J.F. Loos; Cheng Hu; Weiping Jia; Raymond E. Soccio; Mitchell A. Lazar

doi:10.1016/j.stem.2018.11.018

Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response

Wenxiang Hu
, Chunjie Jiang
, Dongyin Guan
, Pieterjan Dierickx
, Rong Zhang
, Arden Moscati
, Girish N. Nadkarni
, David J. Steger
, Ruth J.F. Loos
, Cheng Hu
, Weiping Jia
, Raymond E. Soccio
, Mitchell A. Lazar

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Hu, Jiang, et al. utilize patient adipose stem cell-derived adipocytes to reveal SNPs that modulate the effects of antidiabetic drugs by controlling genomic binding of PPARγ.

Original language	English (US)
Pages (from-to)	299-308.e6
Journal	Cell Stem Cell
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.stem.2018.11.018
State	Published - Feb 7 2019
Externally published	Yes

Keywords

ABCA1
adipocytes
adipose stem cell
antidiabetic drug
drug response
genetic variation
PPARγ
rosiglitazone

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2018.11.018

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@article{23739c36b8e34c538dee4df0143ba2c8,

title = "Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response",

abstract = "Hu, Jiang, et al. utilize patient adipose stem cell-derived adipocytes to reveal SNPs that modulate the effects of antidiabetic drugs by controlling genomic binding of PPARγ.",

keywords = "ABCA1, adipocytes, adipose stem cell, antidiabetic drug, drug response, genetic variation, PPARγ, rosiglitazone",

author = "Wenxiang Hu and Chunjie Jiang and Dongyin Guan and Pieterjan Dierickx and Rong Zhang and Arden Moscati and Nadkarni, \{Girish N.\} and Steger, \{David J.\} and Loos, \{Ruth J.F.\} and Cheng Hu and Weiping Jia and Soccio, \{Raymond E.\} and Lazar, \{Mitchell A.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = feb,

day = "7",

doi = "10.1016/j.stem.2018.11.018",

language = "English (US)",

volume = "24",

pages = "299--308.e6",

journal = "Cell Stem Cell",

issn = "1934-5909",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response

AU - Hu, Wenxiang

AU - Jiang, Chunjie

AU - Guan, Dongyin

AU - Dierickx, Pieterjan

AU - Zhang, Rong

AU - Moscati, Arden

AU - Nadkarni, Girish N.

AU - Steger, David J.

AU - Loos, Ruth J.F.

AU - Hu, Cheng

AU - Jia, Weiping

AU - Soccio, Raymond E.

AU - Lazar, Mitchell A.

PY - 2019/2/7

Y1 - 2019/2/7

N2 - Hu, Jiang, et al. utilize patient adipose stem cell-derived adipocytes to reveal SNPs that modulate the effects of antidiabetic drugs by controlling genomic binding of PPARγ.

AB - Hu, Jiang, et al. utilize patient adipose stem cell-derived adipocytes to reveal SNPs that modulate the effects of antidiabetic drugs by controlling genomic binding of PPARγ.

KW - ABCA1

KW - adipocytes

KW - adipose stem cell

KW - antidiabetic drug

KW - drug response

KW - genetic variation

KW - PPARγ

KW - rosiglitazone

UR - https://www.scopus.com/pages/publications/85060617504

UR - https://www.scopus.com/pages/publications/85060617504#tab=citedBy

U2 - 10.1016/j.stem.2018.11.018

DO - 10.1016/j.stem.2018.11.018

M3 - Article

C2 - 30639037

AN - SCOPUS:85060617504

SN - 1934-5909

VL - 24

SP - 299-308.e6

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 2

ER -

Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response

Abstract

Keywords

ASJC Scopus subject areas

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