Patient-derived tumor xenograft: Present and future challenges and applications

G. Inghirami; P. T. Tinkey; E. de Stanchina; R. K. Uthamanthil

doi:10.1016/B978-0-12-804010-2.00027-8

Patient-derived tumor xenograft: Present and future challenges and applications

G. Inghirami, P. T. Tinkey, E. de Stanchina, R. K. Uthamanthil

Veterinary Medicine & Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Patient-derived tumor xenografts have suddenly emerged as a highly desirable platform in oncology. Many applications have been explored and many others are on the horizon, all with the main objective of improving molecular and biological discoveries, executing more effective drug screenings, and providing new patient customized therapies. Although impressive results have already been rapidly achieved, many questions remain and newer applications continue to be explored. In this chapter, we review the most pressing issues and proposed possible solutions. Future challenges and innovative applications have been introduced.

Original language	English (US)
Title of host publication	Patient Derived Tumor Xenograft Models
Subtitle of host publication	Promise, Potential and Practice
Publisher	Elsevier Inc.
Pages	429-451
Number of pages	23
ISBN (Electronic)	9780128040614
ISBN (Print)	9780128040102
DOIs	https://doi.org/10.1016/B978-0-12-804010-2.00027-8
State	Published - 2017

Keywords

Animal model
Biological specimen banks
Cell line
Heterografts
Mice
Patient-derived xenograft
Personalized cancer therapy
Translational medical research

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-12-804010-2.00027-8

Cite this

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AB - Patient-derived tumor xenografts have suddenly emerged as a highly desirable platform in oncology. Many applications have been explored and many others are on the horizon, all with the main objective of improving molecular and biological discoveries, executing more effective drug screenings, and providing new patient customized therapies. Although impressive results have already been rapidly achieved, many questions remain and newer applications continue to be explored. In this chapter, we review the most pressing issues and proposed possible solutions. Future challenges and innovative applications have been introduced.

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KW - Mice

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KW - Personalized cancer therapy

KW - Translational medical research

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Patient-derived tumor xenograft: Present and future challenges and applications

Abstract

Keywords

ASJC Scopus subject areas

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