Patient-reported Symptom Outcomes and Microsatellite Instability in Patients With Metastatic Colorectal Cancer

Shailesh M. Advani; Quilling Shi; Michael J. Overman; Jonathan M. Loree; Michael Lam; Van Morris; Imad Shureiqi; Bryan Kee; Arvind Dasari; Eduardo Vilar; Amir Mehrvarz Sarshekeh; Huei K. Lin; Shanequa Manuel; Stan Hamilton; Kanwal Raghav; Dipen Maru; Scott Kopetz; Xin Shelley Wang

doi:10.1016/j.clcc.2019.10.006

Patient-reported Symptom Outcomes and Microsatellite Instability in Patients With Metastatic Colorectal Cancer

Shailesh M. Advani, Quilling Shi, Michael J. Overman, Jonathan M. Loree, Michael Lam, Van Morris, Imad Shureiqi, Bryan Kee, Arvind Dasari, Eduardo Vilar, Amir Mehrvarz Sarshekeh, Huei K. Lin, Shanequa Manuel, Stan Hamilton, Kanwal Raghav, Dipen Maru, Scott Kopetz, Xin Shelley Wang

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

In patients with metastatic colorectal cancer, microsatellite instability was associated with a greater symptom burden, and high levels of CpG island methylator subtype were associated with greater pain. The role of microsatellite instability–associated tumor features, including histologic and immune features in potentially increasing the symptom burden in metastatic colorectal cancer warrants further investigation.

Original language	English (US)
Pages (from-to)	48-56.e2
Journal	Clinical colorectal cancer
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/j.clcc.2019.10.006
State	Published - Mar 2020

Keywords

Epigenetics
Microsatellite instability
Patient reported outcomes
Survivorship
Symptom burden

ASJC Scopus subject areas

Oncology
Gastroenterology

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10.1016/j.clcc.2019.10.006

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Advani, S. M., Shi, Q., Overman, M. J., Loree, J. M., Lam, M., Morris, V., Shureiqi, I., Kee, B., Dasari, A., Vilar, E., Sarshekeh, A. M., Lin, H. K., Manuel, S., Hamilton, S., Raghav, K., Maru, D., Kopetz, S., & Wang, X. S. (2020). Patient-reported Symptom Outcomes and Microsatellite Instability in Patients With Metastatic Colorectal Cancer. Clinical colorectal cancer, 19(1), 48-56.e2. https://doi.org/10.1016/j.clcc.2019.10.006

Advani, SM, Shi, Q, Overman, MJ, Loree, JM, Lam, M, Morris, V, Shureiqi, I, Kee, B , Dasari, A , Vilar, E, Sarshekeh, AM, Lin, HK, Manuel, S, Hamilton, S, Raghav, K , Maru, D , Kopetz, S & Wang, XS 2020, 'Patient-reported Symptom Outcomes and Microsatellite Instability in Patients With Metastatic Colorectal Cancer', Clinical colorectal cancer, vol. 19, no. 1, pp. 48-56.e2. https://doi.org/10.1016/j.clcc.2019.10.006

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title = "Patient-reported Symptom Outcomes and Microsatellite Instability in Patients With Metastatic Colorectal Cancer",

abstract = "In patients with metastatic colorectal cancer, microsatellite instability was associated with a greater symptom burden, and high levels of CpG island methylator subtype were associated with greater pain. The role of microsatellite instability–associated tumor features, including histologic and immune features in potentially increasing the symptom burden in metastatic colorectal cancer warrants further investigation.",

keywords = "Epigenetics, Microsatellite instability, Patient reported outcomes, Survivorship, Symptom burden",

author = "Advani, {Shailesh M.} and Quilling Shi and Overman, {Michael J.} and Loree, {Jonathan M.} and Michael Lam and Van Morris and Imad Shureiqi and Bryan Kee and Arvind Dasari and Eduardo Vilar and Sarshekeh, {Amir Mehrvarz} and Lin, {Huei K.} and Shanequa Manuel and Stan Hamilton and Kanwal Raghav and Dipen Maru and Scott Kopetz and Wang, {Xin Shelley}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2020",

month = mar,

doi = "10.1016/j.clcc.2019.10.006",

language = "English (US)",

volume = "19",

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T1 - Patient-reported Symptom Outcomes and Microsatellite Instability in Patients With Metastatic Colorectal Cancer

AU - Advani, Shailesh M.

AU - Shi, Quilling

AU - Overman, Michael J.

AU - Loree, Jonathan M.

AU - Lam, Michael

AU - Morris, Van

AU - Shureiqi, Imad

AU - Kee, Bryan

AU - Dasari, Arvind

AU - Vilar, Eduardo

AU - Sarshekeh, Amir Mehrvarz

AU - Lin, Huei K.

AU - Manuel, Shanequa

AU - Hamilton, Stan

AU - Raghav, Kanwal

AU - Maru, Dipen

AU - Kopetz, Scott

AU - Wang, Xin Shelley

PY - 2020/3

Y1 - 2020/3

N2 - In patients with metastatic colorectal cancer, microsatellite instability was associated with a greater symptom burden, and high levels of CpG island methylator subtype were associated with greater pain. The role of microsatellite instability–associated tumor features, including histologic and immune features in potentially increasing the symptom burden in metastatic colorectal cancer warrants further investigation.

AB - In patients with metastatic colorectal cancer, microsatellite instability was associated with a greater symptom burden, and high levels of CpG island methylator subtype were associated with greater pain. The role of microsatellite instability–associated tumor features, including histologic and immune features in potentially increasing the symptom burden in metastatic colorectal cancer warrants further investigation.

KW - Epigenetics

KW - Microsatellite instability

KW - Patient reported outcomes

KW - Survivorship

KW - Symptom burden

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AN - SCOPUS:85078747000

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SP - 48-56.e2

JO - Clinical colorectal cancer

JF - Clinical colorectal cancer

IS - 1

ER -

Patient-reported Symptom Outcomes and Microsatellite Instability in Patients With Metastatic Colorectal Cancer

Abstract

Keywords

ASJC Scopus subject areas

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