TY - JOUR
T1 - Patterns and predictors of outpatient opioid use after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy
AU - Owusu-Agyemang, Pascal
AU - Cata, Juan P.
AU - Kapoor, Ravish
AU - Speer, Barbra B.
AU - Bellard, Bobby
AU - Feng, Lei
AU - Gottumukkala, Vijaya
N1 - Funding Information:
Editorial support was provided by Bryan Tutt in Scientific Publications Services, Research Medical Library of The University of Texas MD Anderson Cancer Center.
Publisher Copyright:
© 2019, © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Long-term opioid use is a well-known complication after surgery. In this retrospective study of adults who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), we sought to determine the rates and factors associated with outpatient opioid use within the sixth and twelfth postoperative months. Methods: Records of 288 opioid-naïve patients were included. Logistic regression models were used to determine factors prognostic of outpatient opioid use. Results: The median patient age was 54 years, and 63% were female. Rates of outpatient opioid use within the sixth and twelfth postoperative months were 21 and 13%, respectively. In the multivariate analysis, every doubling in the amount of in-hospital postoperative opioid consumption was associated with a 44% increase in odds of opioid use within the sixth postoperative month (OR 1.44, 95% CI 1.11–1.87, p =.006) and a 70% increase within the twelfth postoperative month (OR 1.70, 95% CI 1.70–2.37, p =.001). Other factors associated with opioid use within the sixth postoperative month included physical status (OR 5.26, 95% CI 1.08–25.55, p =.039) and recent additional surgery (OR 23.02, 95% CI 2.03–261.30, p =.011). Age (OR 4.39, 95% CI 1.77–10.89, p =.001) and tumor grade (OR 3.31, 95% CI 1.31–8.41, p =.012) were associated with opioid use within the twelfth postoperative month. Conclusion: In this study, the amount of in-hospital postoperative opioid consumption was an important contributory factor to outpatient opioid use in the sixth and twelfth postoperative months.Synopsis In this study of adults who had undergone CRS-HIPEC, higher postoperative opioid consumption during hospitalization was associated with higher odds of opioid use within the sixth and twelfth postoperative months.
AB - Background: Long-term opioid use is a well-known complication after surgery. In this retrospective study of adults who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), we sought to determine the rates and factors associated with outpatient opioid use within the sixth and twelfth postoperative months. Methods: Records of 288 opioid-naïve patients were included. Logistic regression models were used to determine factors prognostic of outpatient opioid use. Results: The median patient age was 54 years, and 63% were female. Rates of outpatient opioid use within the sixth and twelfth postoperative months were 21 and 13%, respectively. In the multivariate analysis, every doubling in the amount of in-hospital postoperative opioid consumption was associated with a 44% increase in odds of opioid use within the sixth postoperative month (OR 1.44, 95% CI 1.11–1.87, p =.006) and a 70% increase within the twelfth postoperative month (OR 1.70, 95% CI 1.70–2.37, p =.001). Other factors associated with opioid use within the sixth postoperative month included physical status (OR 5.26, 95% CI 1.08–25.55, p =.039) and recent additional surgery (OR 23.02, 95% CI 2.03–261.30, p =.011). Age (OR 4.39, 95% CI 1.77–10.89, p =.001) and tumor grade (OR 3.31, 95% CI 1.31–8.41, p =.012) were associated with opioid use within the twelfth postoperative month. Conclusion: In this study, the amount of in-hospital postoperative opioid consumption was an important contributory factor to outpatient opioid use in the sixth and twelfth postoperative months.Synopsis In this study of adults who had undergone CRS-HIPEC, higher postoperative opioid consumption during hospitalization was associated with higher odds of opioid use within the sixth and twelfth postoperative months.
KW - Outpatient
KW - cytoreduction
KW - long-term
KW - opioids
KW - surgery
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U2 - 10.1080/02656736.2019.1675912
DO - 10.1080/02656736.2019.1675912
M3 - Article
C2 - 31646916
AN - SCOPUS:85074064153
SN - 0265-6736
VL - 36
SP - 1058
EP - 1064
JO - International Journal of Hyperthermia
JF - International Journal of Hyperthermia
IS - 1
ER -