TY - JOUR
T1 - Patterns of care for pediatric patients with newly-diagnosed grade II gliomas
AU - Taku, Nicolette
AU - Woodhouse, Kristina D.
AU - Liao, Kai Ping
AU - Anakwenze, Chidinma P.
AU - Harrison, Rebecca A.
AU - Zaky, Wafik
AU - Paulino, Arnold C.
AU - Yeboa, Debra N.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
PY - 2021/5
Y1 - 2021/5
N2 - Purpose: We describe large-scale demographic, initial treatment, and outcomes data for pediatric grade II gliomas included in the National Cancer Database from 2004 to 2014. Methods: Our cohort included cases less than 21 years of age with pathology-confirmed disease. Logistic regressions were used to evaluate the use of chemotherapy (CT) and radiation therapy (RT). Overall survival (OS) rates were determined using Kaplan-Meier estimates and the log-rank test. Results: We identified 803 cases with astrocytoma (56.2%), oligodendroglioma (26.0%), and mixed glioma/glioma NOS (17.8%) histologies. Most cases underwent surgical resection (n = 661). Whereas cases 16 to 21 years of age were more likely than cases 0 to 5 years to receive RT (OR = 7.38, 95% CI 3.58–15.21, p < 0.001), they were less likely to receive CT (OR = 0.34, 95% CI 0.22–0.52, p < 0.001). The 5-year OS rates for all cases, cases that underwent surgical resection, and cases managed with biopsy were 87.5%, 92.7%, and 63.6%, respectively. Conclusion: In one of the largest series of pediatric grade II gliomas, astrocytoma was the most common histology. Patterns of care and OS outcomes were similar to grade I gliomas, with surgical resection being the most common initial treatment and associated with a favorable rate of OS. Younger patients were more likely to receive post-operative CT and the use of RT increased with age.
AB - Purpose: We describe large-scale demographic, initial treatment, and outcomes data for pediatric grade II gliomas included in the National Cancer Database from 2004 to 2014. Methods: Our cohort included cases less than 21 years of age with pathology-confirmed disease. Logistic regressions were used to evaluate the use of chemotherapy (CT) and radiation therapy (RT). Overall survival (OS) rates were determined using Kaplan-Meier estimates and the log-rank test. Results: We identified 803 cases with astrocytoma (56.2%), oligodendroglioma (26.0%), and mixed glioma/glioma NOS (17.8%) histologies. Most cases underwent surgical resection (n = 661). Whereas cases 16 to 21 years of age were more likely than cases 0 to 5 years to receive RT (OR = 7.38, 95% CI 3.58–15.21, p < 0.001), they were less likely to receive CT (OR = 0.34, 95% CI 0.22–0.52, p < 0.001). The 5-year OS rates for all cases, cases that underwent surgical resection, and cases managed with biopsy were 87.5%, 92.7%, and 63.6%, respectively. Conclusion: In one of the largest series of pediatric grade II gliomas, astrocytoma was the most common histology. Patterns of care and OS outcomes were similar to grade I gliomas, with surgical resection being the most common initial treatment and associated with a favorable rate of OS. Younger patients were more likely to receive post-operative CT and the use of RT increased with age.
KW - Brain tumors
KW - Gliomas
KW - Grade II
KW - Pediatrics
UR - http://www.scopus.com/inward/record.url?scp=85099240410&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85099240410&partnerID=8YFLogxK
U2 - 10.1007/s00381-020-05002-w
DO - 10.1007/s00381-020-05002-w
M3 - Article
C2 - 33404712
AN - SCOPUS:85099240410
SN - 0256-7040
VL - 37
SP - 1563
EP - 1572
JO - Child's Nervous System
JF - Child's Nervous System
IS - 5
ER -