Abstract
Choroid plexus (CP) carcinoma is a rare pediatric brain neoplasm. Recent studies have highlighted the potential of genome-wide methylation and gene expression profiling to provide additional layers of information to improve tumor risk-stratification. There is a lack of data regarding the best therapy, and approaches have been heterogeneous. Despite multidisciplinary treatment approaches, the outcome remains guarded and treatments have been based on case series and expert opinions. In this study, we discuss the recent wealth of data regarding CP carcinoma molecular biology and current management. We also briefly highlight the remaining barriers to formulate the best treatment strategies, and future therapeutic potentials.
Original language | English (US) |
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Article number | e27031 |
Journal | Pediatric Blood and Cancer |
Volume | 65 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2018 |
Keywords
- biology
- chemotherapy
- choroid plexus carcinoma
- radiation
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology