Pediatric choroid plexus carcinoma: Biologically and clinically in need of new perspectives

Wafik Zaky, Jonathan L. Finlay

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Choroid plexus (CP) carcinoma is a rare pediatric brain neoplasm. Recent studies have highlighted the potential of genome-wide methylation and gene expression profiling to provide additional layers of information to improve tumor risk-stratification. There is a lack of data regarding the best therapy, and approaches have been heterogeneous. Despite multidisciplinary treatment approaches, the outcome remains guarded and treatments have been based on case series and expert opinions. In this study, we discuss the recent wealth of data regarding CP carcinoma molecular biology and current management. We also briefly highlight the remaining barriers to formulate the best treatment strategies, and future therapeutic potentials.

Original languageEnglish (US)
Article numbere27031
JournalPediatric Blood and Cancer
Volume65
Issue number7
DOIs
StatePublished - Jul 2018

Keywords

  • biology
  • chemotherapy
  • choroid plexus carcinoma
  • radiation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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