Peptide-based anticancer vaccines the making and unmaking of a T-cell graveyard

Yared Hailemichael; Willem W. Overwijk

doi:10.4161/onci.24743

Peptide-based anticancer vaccines the making and unmaking of a T-cell graveyard

Yared Hailemichael, Willem W. Overwijk

Melanoma Medical Oncology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Poorly biodegradable, incomplete Freund's adjuvant (IFA)-based anticancer vaccines primed CD8⁺+ T cells that did not localize to the tumor site but to the persisting, antigen-rich vaccination site, which became a T-cell graveyard. Short-lived, water-based formulations and the provision of immunostimulatory molecules overcame this issue, resulting in tumor suppression. Here, we discuss the implications of these findings for the development of therapeutic anticancer vaccines.

Original language	English (US)
Article number	e24743
Journal	OncoImmunology
Volume	2
Issue number	7
DOIs	https://doi.org/10.4161/onci.24743
State	Published - 2013

Keywords

Antigen persistence
Immunotherapy
Sequestration
T-cell deletion
T-cell dysfunction
T-cell trafficking
Vaccine depot

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.24743

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abstract = "Poorly biodegradable, incomplete Freund's adjuvant (IFA)-based anticancer vaccines primed CD8++ T cells that did not localize to the tumor site but to the persisting, antigen-rich vaccination site, which became a T-cell graveyard. Short-lived, water-based formulations and the provision of immunostimulatory molecules overcame this issue, resulting in tumor suppression. Here, we discuss the implications of these findings for the development of therapeutic anticancer vaccines.",

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Peptide-based anticancer vaccines the making and unmaking of a T-cell graveyard

Abstract

Keywords

ASJC Scopus subject areas

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