Perioperative period, stress response, immune suppression and cancer recurrence

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

During the perioperative of any major surgery, there is an intense activation of the sympathetic nervous system, the hypothalamus-pituitaryadrenal axis, and several cellular and soluble components of the inflammatory cascade. All together elements are part so-called stress response. Two characteristics of an exaggerated and uncontrolled stress response are exhaustion and immune suppression. This last, in particular, is relevant in the context of cancer surgery because can lead to growth of any potential postoperative minimal residual disease. To complicate more this matter, anesthetics, opioids and blood transfusions can also contribute to the so-called perioperative immune suppression and cancer growth. Hence, surgeons and anesthesiologist have tried to developed pharmacological and non-pharmacological interventions targeted to avoid the unwanted effects of an exaggerated stress response.

Original languageEnglish (US)
Title of host publicationGeneral and Abdominal Surgery
Subtitle of host publicationPractices, Potential Complications and Postoperative Management and Outcomes
PublisherNova Science Publishers, Inc.
Pages77-99
Number of pages23
ISBN (Electronic)9781631174414
ISBN (Print)9781631174407
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • General Medicine

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