Peritoneal carcinomatosis of colon cancer origin: Highest incidence in women and in patients with right-sided tumors

Ole Helmer Sjo, Marianne Berg, Marianne Arstad Merok, Matthias Kolberg, Aud Svindland, Ragnhild A. Lothe, Arild Nesbakken

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background and Objectives: The aim of the study was to evaluate the incidence of peritoneal carcinomatosis (PC) in a prospectively recorded series of colon cancer patients from a defined cohort and to compare clinicopathological characteristics, survival, and TP53 mutation status in primary tumors from patients with and without PC. Methods: Clinical data from all colon cancer patients admitted in 1993-2006 were registered prospectively (n = 1,124). In a subset of PC patients, DNA was retrieved from tumor tissue and TP53 mutations analyzed and compared to the mutation status in a historical series. Results: In the prospective series 10% of female and 7% of male patients had PC (P = 0.05). The PC patients were younger than those without PC (median 4 years, P = 0.002). The incidence of PC was 10.3% and 6.2% (P = 0.03) in patients with primary tumors in the right and left colon, respectively. TP53 was mutated in 57% of the PC patients as compared to 41% in the series of patients without PC (P = 0.05). Conclusions: The incidence of PC was higher in right-sided colon cancer and among women. PC patients were younger than non-PC patients, and PC was independently associated with TP53 mutation in the primary tumor. J. Surg. Oncol. © 2011 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)792-797
Number of pages6
JournalJournal of surgical oncology
Volume104
Issue number7
DOIs
StatePublished - Dec 1 2011

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Patient Rights
Colonic Neoplasms
Carcinoma
Incidence
Neoplasms
Mutation
Colon

Keywords

  • TP53 mutation
  • colon cancer
  • peritoneal carcinomatosis
  • tumor location

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Peritoneal carcinomatosis of colon cancer origin : Highest incidence in women and in patients with right-sided tumors. / Sjo, Ole Helmer; Berg, Marianne; Merok, Marianne Arstad; Kolberg, Matthias; Svindland, Aud; Lothe, Ragnhild A.; Nesbakken, Arild.

In: Journal of surgical oncology, Vol. 104, No. 7, 01.12.2011, p. 792-797.

Research output: Contribution to journalArticle

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