Personalized Medicine: Patient-Predictive Panel Power

Paul Workman; Paul A. Clarke; Bissan Al-Lazikani

doi:10.1016/j.ccr.2012.03.030

Personalized Medicine: Patient-Predictive Panel Power

Paul Workman
, Paul A. Clarke
, Bissan Al-Lazikani

Research output: Contribution to journal › Short survey › peer-review

14 Scopus citations

Abstract

Two recent papers published in Nature demonstrate the power of systematic high-throughput pharmacologic profiling of very large, diverse, molecularly-characterized human cancer cell line panels to reveal linkages between genetic profile and targeted-drug sensitivity. Known oncogene addictions are confirmed while surprising complexities and biomarker relationships with clinical potential are revealed.

Original language	English (US)
Pages (from-to)	455-458
Number of pages	4
Journal	Cancer cell
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/j.ccr.2012.03.030
State	Published - Apr 17 2012
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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10.1016/j.ccr.2012.03.030

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@article{f026238842d94e32bc8f418f46cbb4a7,

title = "Personalized Medicine: Patient-Predictive Panel Power",

abstract = "Two recent papers published in Nature demonstrate the power of systematic high-throughput pharmacologic profiling of very large, diverse, molecularly-characterized human cancer cell line panels to reveal linkages between genetic profile and targeted-drug sensitivity. Known oncogene addictions are confirmed while surprising complexities and biomarker relationships with clinical potential are revealed.",

author = "Paul Workman and Clarke, \{Paul A.\} and Bissan Al-Lazikani",

year = "2012",

month = apr,

day = "17",

doi = "10.1016/j.ccr.2012.03.030",

language = "English (US)",

volume = "21",

pages = "455--458",

journal = "Cancer cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - Personalized Medicine

T2 - Patient-Predictive Panel Power

AU - Workman, Paul

AU - Clarke, Paul A.

AU - Al-Lazikani, Bissan

PY - 2012/4/17

Y1 - 2012/4/17

N2 - Two recent papers published in Nature demonstrate the power of systematic high-throughput pharmacologic profiling of very large, diverse, molecularly-characterized human cancer cell line panels to reveal linkages between genetic profile and targeted-drug sensitivity. Known oncogene addictions are confirmed while surprising complexities and biomarker relationships with clinical potential are revealed.

AB - Two recent papers published in Nature demonstrate the power of systematic high-throughput pharmacologic profiling of very large, diverse, molecularly-characterized human cancer cell line panels to reveal linkages between genetic profile and targeted-drug sensitivity. Known oncogene addictions are confirmed while surprising complexities and biomarker relationships with clinical potential are revealed.

UR - https://www.scopus.com/pages/publications/84859848953

UR - https://www.scopus.com/pages/publications/84859848953#tab=citedBy

U2 - 10.1016/j.ccr.2012.03.030

DO - 10.1016/j.ccr.2012.03.030

M3 - Short survey

C2 - 22516256

AN - SCOPUS:84859848953

SN - 1535-6108

VL - 21

SP - 455

EP - 458

JO - Cancer cell

JF - Cancer cell

IS - 4

ER -

Personalized Medicine: Patient-Predictive Panel Power

Abstract

ASJC Scopus subject areas

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