Pharmacodynamic relationship of pharmacokinetic parameters of maintenance doses of foscarnet and clinical outcome of cytomegalovirus retinitis

M. A. Jacobson, B. Polsky, D. Causey, R. Davis, W. Tong, J. J. O'Donnell, B. D. Kuppermann, M. H. Heinemann, J. Feinberg, P. Lizak, J. G. Gambertoglio, F. T. Aweeka

Research output: Contribution to journalComment/debatepeer-review

7 Scopus citations

Abstract

The pharmacodynamic relationship between a range of foscarnet exposure measurements obtained from studying nine patients receiving ongoing maintenance therapy for cytomegalovirus retinitis and a range of efficacy values (days to retinitis progression) obtained by independent examination of serial retinal photographs from the same nine patients was analyzed. In the resulting proportional hazards models, the foscarnet area under the concentration-time curve approached statistical significance (P = 0.11) as a predictor of decreased risk of retinitis progression.

Original languageEnglish (US)
Pages (from-to)1190-1193
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume38
Issue number5
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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