Photoacoustic- And magnetic resonance-guided photothermal therapy and tumor vasculature visualization using theranostic magnetic gold nanoshells

Min Zhou; Burapol Singhana; Yang Liu; Qian Huang; Trevor Mitcham; Michael J. Wallace; R. Jason Stafford; Richard R. Bouchard; Marites P. Melancon

doi:10.1166/jbn.2015.2089

Photoacoustic- And magnetic resonance-guided photothermal therapy and tumor vasculature visualization using theranostic magnetic gold nanoshells

Min Zhou, Burapol Singhana, Yang Liu, Qian Huang, Trevor Mitcham, Michael J. Wallace, R. Jason Stafford, Richard R. Bouchard, Marites P. Melancon

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Nanoparticle based image-guided therapy is an emerging technology for cancer in recent years. Here,we report simultaneous photoacoustic (PA)- and magnetic resonance (MR)-guided photothermal ablation (PTA) therapy using multifunctional superparamagnetic iron oxide-containing gold nanoshells (SPIO@AuNS). Based on the intrinsic high near-infrared optical absorbance and strong magnetic property of SPIO@AuNS, we carried out in vivo dual-modality PA-MR imaging of mouse tumors. PA- and MR-guided imaging can monitor therapeutic effect after photothermal therapy mediated by our multifunctional nanomaterial. In addition, using our pulsed laser PA technique, we also observe a clearer structure of the tumor vasculature after intravenously administration novel dual PA-MRI image-guided PTA therapy provides a promising new platform for cancer diagnosis and treatment simultaneously.

Original language	English (US)
Pages (from-to)	1385-1400
Number of pages	16
Journal	Journal of biomedical nanotechnology
Volume	11
Issue number	8
DOIs	https://doi.org/10.1166/jbn.2015.2089
State	Published - Aug 1 2014

Keywords

Imaging guided therapy.
Magnetic resonance imaging
Nanoparticles
Photoacoustic imaging
Photothermal therapy

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science
Pharmaceutical Science

MD Anderson CCSG core facilities

Research Animal Support Facility
Small Animal Imaging Facility

Access to Document

10.1166/jbn.2015.2089

Cite this

Zhou, M., Singhana, B., Liu, Y., Huang, Q., Mitcham, T., Wallace, M. J., Stafford, R. J., Bouchard, R. R., & Melancon, M. P. (2014). Photoacoustic- And magnetic resonance-guided photothermal therapy and tumor vasculature visualization using theranostic magnetic gold nanoshells. Journal of biomedical nanotechnology, 11(8), 1385-1400. https://doi.org/10.1166/jbn.2015.2089

@article{d51130ba47234a8a9481dd3ff712c7a8,

title = "Photoacoustic- And magnetic resonance-guided photothermal therapy and tumor vasculature visualization using theranostic magnetic gold nanoshells",

abstract = "Nanoparticle based image-guided therapy is an emerging technology for cancer in recent years. Here,we report simultaneous photoacoustic (PA)- and magnetic resonance (MR)-guided photothermal ablation (PTA) therapy using multifunctional superparamagnetic iron oxide-containing gold nanoshells (SPIO@AuNS). Based on the intrinsic high near-infrared optical absorbance and strong magnetic property of SPIO@AuNS, we carried out in vivo dual-modality PA-MR imaging of mouse tumors. PA- and MR-guided imaging can monitor therapeutic effect after photothermal therapy mediated by our multifunctional nanomaterial. In addition, using our pulsed laser PA technique, we also observe a clearer structure of the tumor vasculature after intravenously administration novel dual PA-MRI image-guided PTA therapy provides a promising new platform for cancer diagnosis and treatment simultaneously.",

keywords = "Imaging guided therapy., Magnetic resonance imaging, Nanoparticles, Photoacoustic imaging, Photothermal therapy",

author = "Min Zhou and Burapol Singhana and Yang Liu and Qian Huang and Trevor Mitcham and Wallace, {Michael J.} and Stafford, {R. Jason} and Bouchard, {Richard R.} and Melancon, {Marites P.}",

year = "2014",

month = aug,

day = "1",

doi = "10.1166/jbn.2015.2089",

language = "English (US)",

volume = "11",

pages = "1385--1400",

journal = "Journal of biomedical nanotechnology",

issn = "1550-7033",

publisher = "American Scientific Publishers",

number = "8",

}

TY - JOUR

T1 - Photoacoustic- And magnetic resonance-guided photothermal therapy and tumor vasculature visualization using theranostic magnetic gold nanoshells

AU - Zhou, Min

AU - Singhana, Burapol

AU - Liu, Yang

AU - Huang, Qian

AU - Mitcham, Trevor

AU - Wallace, Michael J.

AU - Stafford, R. Jason

AU - Bouchard, Richard R.

AU - Melancon, Marites P.

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Nanoparticle based image-guided therapy is an emerging technology for cancer in recent years. Here,we report simultaneous photoacoustic (PA)- and magnetic resonance (MR)-guided photothermal ablation (PTA) therapy using multifunctional superparamagnetic iron oxide-containing gold nanoshells (SPIO@AuNS). Based on the intrinsic high near-infrared optical absorbance and strong magnetic property of SPIO@AuNS, we carried out in vivo dual-modality PA-MR imaging of mouse tumors. PA- and MR-guided imaging can monitor therapeutic effect after photothermal therapy mediated by our multifunctional nanomaterial. In addition, using our pulsed laser PA technique, we also observe a clearer structure of the tumor vasculature after intravenously administration novel dual PA-MRI image-guided PTA therapy provides a promising new platform for cancer diagnosis and treatment simultaneously.

AB - Nanoparticle based image-guided therapy is an emerging technology for cancer in recent years. Here,we report simultaneous photoacoustic (PA)- and magnetic resonance (MR)-guided photothermal ablation (PTA) therapy using multifunctional superparamagnetic iron oxide-containing gold nanoshells (SPIO@AuNS). Based on the intrinsic high near-infrared optical absorbance and strong magnetic property of SPIO@AuNS, we carried out in vivo dual-modality PA-MR imaging of mouse tumors. PA- and MR-guided imaging can monitor therapeutic effect after photothermal therapy mediated by our multifunctional nanomaterial. In addition, using our pulsed laser PA technique, we also observe a clearer structure of the tumor vasculature after intravenously administration novel dual PA-MRI image-guided PTA therapy provides a promising new platform for cancer diagnosis and treatment simultaneously.

KW - Imaging guided therapy.

KW - Magnetic resonance imaging

KW - Nanoparticles

KW - Photoacoustic imaging

KW - Photothermal therapy

UR - http://www.scopus.com/inward/record.url?scp=84919913408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919913408&partnerID=8YFLogxK

U2 - 10.1166/jbn.2015.2089

DO - 10.1166/jbn.2015.2089

M3 - Article

C2 - 26295144

AN - SCOPUS:84919913408

SN - 1550-7033

VL - 11

SP - 1385

EP - 1400

JO - Journal of biomedical nanotechnology

JF - Journal of biomedical nanotechnology

IS - 8

ER -

Photoacoustic- And magnetic resonance-guided photothermal therapy and tumor vasculature visualization using theranostic magnetic gold nanoshells

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

Other files and links

Fingerprint

Cite this