Photoacoustic imaging with biodegradable plasmonic nanoclusters

Soon Joon Yoon; Srivalleesha Mallidi; Jasmine M. Tam; Justina O. Tam; Avinash Murthy; Keith P. Johnston; Konstantin V. Sokolov; Stanislav Y. Emelianov

doi:10.1109/ULTSYM.2010.5935805

Photoacoustic imaging with biodegradable plasmonic nanoclusters

Soon Joon Yoon, Srivalleesha Mallidi, Jasmine M. Tam, Justina O. Tam, Avinash Murthy, Keith P. Johnston, Konstantin V. Sokolov, Stanislav Y. Emelianov

Imaging Physics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Plasmonic nanoparticles have been widely used for various biomedical applications such as biological imaging, sensing, and cancer therapy. Specifically, gold nanospheres, nanorods, and nanoshells are used as contrast agents for photoacoustic imaging due to their strong absorptive property. However, there are concerns about using these nanoparticles in-vivo because they are not biodegradable and cannot be cleared from the body. Recently, biodegradable nanoclusters have been reported. The biodegradable nanoparticles are composed of primary 4-nm gold nanoparticles and stabilized by a biodegradable polymer binder. In this study, we demonstrated the utility of biodegradable nanoclusters as a contrast agent in photoacoustic imaging. The tissue mimicking phantoms were used for ultrasound and photoacoustic imaging. The results show that the biodegradable plasmonic nanoclusters can be used as photoacoustic contrast agent.

Original language	English (US)
Title of host publication	2010 IEEE International Ultrasonics Symposium, IUS 2010
Pages	1011-1014
Number of pages	4
DOIs	https://doi.org/10.1109/ULTSYM.2010.5935805
State	Published - 2010
Event	2010 IEEE International Ultrasonics Symposium, IUS 2010 - San Diego, CA, United States Duration: Oct 11 2010 → Oct 14 2010

Publication series

Name	Proceedings - IEEE Ultrasonics Symposium
ISSN (Print)	1051-0117

Other

Other	2010 IEEE International Ultrasonics Symposium, IUS 2010
Country/Territory	United States
City	San Diego, CA
Period	10/11/10 → 10/14/10

Keywords

biodegradable
gold nanoparticles
optoacoustic imaging
photoacoustic imaging
plasmon coupling
plasmonic nanoparticles

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2010.5935805

Cite this

Yoon, SJ, Mallidi, S, Tam, JM, Tam, JO, Murthy, A, Johnston, KP, Sokolov, KV & Emelianov, SY 2010, Photoacoustic imaging with biodegradable plasmonic nanoclusters. in 2010 IEEE International Ultrasonics Symposium, IUS 2010., 5935805, Proceedings - IEEE Ultrasonics Symposium, pp. 1011-1014, 2010 IEEE International Ultrasonics Symposium, IUS 2010, San Diego, CA, United States, 10/11/10. https://doi.org/10.1109/ULTSYM.2010.5935805

@inproceedings{b620eef28228414b842f47d96a9a0492,

title = "Photoacoustic imaging with biodegradable plasmonic nanoclusters",

abstract = "Plasmonic nanoparticles have been widely used for various biomedical applications such as biological imaging, sensing, and cancer therapy. Specifically, gold nanospheres, nanorods, and nanoshells are used as contrast agents for photoacoustic imaging due to their strong absorptive property. However, there are concerns about using these nanoparticles in-vivo because they are not biodegradable and cannot be cleared from the body. Recently, biodegradable nanoclusters have been reported. The biodegradable nanoparticles are composed of primary 4-nm gold nanoparticles and stabilized by a biodegradable polymer binder. In this study, we demonstrated the utility of biodegradable nanoclusters as a contrast agent in photoacoustic imaging. The tissue mimicking phantoms were used for ultrasound and photoacoustic imaging. The results show that the biodegradable plasmonic nanoclusters can be used as photoacoustic contrast agent.",

keywords = "biodegradable, gold nanoparticles, optoacoustic imaging, photoacoustic imaging, plasmon coupling, plasmonic nanoparticles",

author = "Yoon, {Soon Joon} and Srivalleesha Mallidi and Tam, {Jasmine M.} and Tam, {Justina O.} and Avinash Murthy and Johnston, {Keith P.} and Sokolov, {Konstantin V.} and Emelianov, {Stanislav Y.}",

year = "2010",

doi = "10.1109/ULTSYM.2010.5935805",

language = "English (US)",

isbn = "9781457703829",

series = "Proceedings - IEEE Ultrasonics Symposium",

pages = "1011--1014",

booktitle = "2010 IEEE International Ultrasonics Symposium, IUS 2010",

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AU - Yoon, Soon Joon

AU - Mallidi, Srivalleesha

AU - Tam, Jasmine M.

AU - Tam, Justina O.

AU - Murthy, Avinash

AU - Johnston, Keith P.

AU - Sokolov, Konstantin V.

AU - Emelianov, Stanislav Y.

PY - 2010

Y1 - 2010

N2 - Plasmonic nanoparticles have been widely used for various biomedical applications such as biological imaging, sensing, and cancer therapy. Specifically, gold nanospheres, nanorods, and nanoshells are used as contrast agents for photoacoustic imaging due to their strong absorptive property. However, there are concerns about using these nanoparticles in-vivo because they are not biodegradable and cannot be cleared from the body. Recently, biodegradable nanoclusters have been reported. The biodegradable nanoparticles are composed of primary 4-nm gold nanoparticles and stabilized by a biodegradable polymer binder. In this study, we demonstrated the utility of biodegradable nanoclusters as a contrast agent in photoacoustic imaging. The tissue mimicking phantoms were used for ultrasound and photoacoustic imaging. The results show that the biodegradable plasmonic nanoclusters can be used as photoacoustic contrast agent.

AB - Plasmonic nanoparticles have been widely used for various biomedical applications such as biological imaging, sensing, and cancer therapy. Specifically, gold nanospheres, nanorods, and nanoshells are used as contrast agents for photoacoustic imaging due to their strong absorptive property. However, there are concerns about using these nanoparticles in-vivo because they are not biodegradable and cannot be cleared from the body. Recently, biodegradable nanoclusters have been reported. The biodegradable nanoparticles are composed of primary 4-nm gold nanoparticles and stabilized by a biodegradable polymer binder. In this study, we demonstrated the utility of biodegradable nanoclusters as a contrast agent in photoacoustic imaging. The tissue mimicking phantoms were used for ultrasound and photoacoustic imaging. The results show that the biodegradable plasmonic nanoclusters can be used as photoacoustic contrast agent.

KW - biodegradable

KW - gold nanoparticles

KW - optoacoustic imaging

KW - photoacoustic imaging

KW - plasmon coupling

KW - plasmonic nanoparticles

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M3 - Conference contribution

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SN - 9781457703829

T3 - Proceedings - IEEE Ultrasonics Symposium

SP - 1011

EP - 1014

BT - 2010 IEEE International Ultrasonics Symposium, IUS 2010

T2 - 2010 IEEE International Ultrasonics Symposium, IUS 2010

Y2 - 11 October 2010 through 14 October 2010

ER -

Photoacoustic imaging with biodegradable plasmonic nanoclusters

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Keywords

ASJC Scopus subject areas

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