Photoacoustic tomography and molecular fluorescence imaging: Dual modality imaging of small animal brains in vivo

Xueyi Xie, Jung Taek Oh, Meng Lin Li, Geng Ku, Xueding Wang, Shi Ke, Chun Li, Sergiu Similache, George Stoica, Lihong V. Wang

Research output: Contribution to journalConference articlepeer-review

5 Scopus citations

Abstract

We present a dual modality imaging technique by combining photoacoustic tomography (PAT) and near-infrared (NIR) fluorescence imaging for the study of animal model tumors. PAT provides high-resolution structural images of tumor angiogenesis, and fluorescence imaging offers high sensitivity to molecular probes for tumor detection. Coregistration of the PAT and fluorescence images was performed on nude mice with M21 human melanoma cell lines with ανβ3 integrin expression. An integrin ανβ3-targeted peptide-ICG conjugated NIR fluorescent contrast agent was used as the molecular probe for tumor detection. PAT was employed to noninvasively image the brain structures and the angiogenesis associated with tumors in nude mice. Coregistration of the PAT and fluorescence images was used in this study to visualize tumor location, angiogenesis, and brain structure simultaneously.

Original languageEnglish (US)
Article number19
Pages (from-to)107-110
Number of pages4
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume5697
DOIs
StatePublished - 2005
EventSixth Conference on Biomedical Thermosacoustics, Optoacoustics, and Acousto-Optics - Photons Plus Ultrasound: Imaging and Sensing 2005 - San Jose, CA, United States
Duration: Jan 23 2005Jan 25 2005

Keywords

  • Contrast agent
  • Fluorescent imaging
  • Molecular imaging
  • Photoacoustic tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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