Abstract
We present a dual modality imaging technique by combining photoacoustic tomography (PAT) and near-infrared (NIR) fluorescence imaging for the study of animal model tumors. PAT provides high-resolution structural images of tumor angiogenesis, and fluorescence imaging offers high sensitivity to molecular probes for tumor detection. Coregistration of the PAT and fluorescence images was performed on nude mice with M21 human melanoma cell lines with ανβ3 integrin expression. An integrin ανβ3-targeted peptide-ICG conjugated NIR fluorescent contrast agent was used as the molecular probe for tumor detection. PAT was employed to noninvasively image the brain structures and the angiogenesis associated with tumors in nude mice. Coregistration of the PAT and fluorescence images was used in this study to visualize tumor location, angiogenesis, and brain structure simultaneously.
Original language | English (US) |
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Article number | 19 |
Pages (from-to) | 107-110 |
Number of pages | 4 |
Journal | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
Volume | 5697 |
DOIs | |
State | Published - 2005 |
Event | Sixth Conference on Biomedical Thermosacoustics, Optoacoustics, and Acousto-Optics - Photons Plus Ultrasound: Imaging and Sensing 2005 - San Jose, CA, United States Duration: Jan 23 2005 → Jan 25 2005 |
Keywords
- Contrast agent
- Fluorescent imaging
- Molecular imaging
- Photoacoustic tomography
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Radiology Nuclear Medicine and imaging