Photodynamic therapy: An alternative technique to cervical conization for cervical dysplasia

Jeffrey A. How; Amir A. Jazaeri

doi:10.1016/j.medj.2025.100922

Photodynamic therapy: An alternative technique to cervical conization for cervical dysplasia

Gynecological Oncology & Reproductive Medicine

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Predominantly prevalent in women of reproductive age, high-grade cervical dysplasia and its subsequent management can be challenging and significantly impact fertility goals. In a randomized controlled phase III trial, Chen et al. demonstrate that photodynamic therapy with APL-1702 is better than placebo for regression of CIN2 lesions and has a good safety profile; further investigations are warranted before it can enter standard clinical practice.¹

Original language	English (US)
Article number	100922
Journal	Med
Volume	6
Issue number	12
DOIs	https://doi.org/10.1016/j.medj.2025.100922
State	Published - Dec 12 2025

ASJC Scopus subject areas

General Medicine

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10.1016/j.medj.2025.100922

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title = "Photodynamic therapy: An alternative technique to cervical conization for cervical dysplasia",

abstract = "Predominantly prevalent in women of reproductive age, high-grade cervical dysplasia and its subsequent management can be challenging and significantly impact fertility goals. In a randomized controlled phase III trial, Chen et al. demonstrate that photodynamic therapy with APL-1702 is better than placebo for regression of CIN2 lesions and has a good safety profile; further investigations are warranted before it can enter standard clinical practice.1",

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AU - Jazaeri, Amir A.

PY - 2025/12/12

Y1 - 2025/12/12

N2 - Predominantly prevalent in women of reproductive age, high-grade cervical dysplasia and its subsequent management can be challenging and significantly impact fertility goals. In a randomized controlled phase III trial, Chen et al. demonstrate that photodynamic therapy with APL-1702 is better than placebo for regression of CIN2 lesions and has a good safety profile; further investigations are warranted before it can enter standard clinical practice.1

AB - Predominantly prevalent in women of reproductive age, high-grade cervical dysplasia and its subsequent management can be challenging and significantly impact fertility goals. In a randomized controlled phase III trial, Chen et al. demonstrate that photodynamic therapy with APL-1702 is better than placebo for regression of CIN2 lesions and has a good safety profile; further investigations are warranted before it can enter standard clinical practice.1

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UR - https://www.scopus.com/pages/publications/105024347230#tab=citedBy

U2 - 10.1016/j.medj.2025.100922

DO - 10.1016/j.medj.2025.100922

M3 - Comment/debate

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VL - 6

JO - Med

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Photodynamic therapy: An alternative technique to cervical conization for cervical dysplasia

Abstract

ASJC Scopus subject areas

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