TY - JOUR
T1 - Physical function predicts mortality in patients with cancer
T2 - a systematic review and meta-analysis of observational studies
AU - Nakano, Jiro
AU - Fukushima, Takuya
AU - Tanaka, Takashi
AU - Fu, Jack B.
AU - Morishita, Shinichiro
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: this study was partly supported by JSPS KAKENHI Grant Number 18K10711 as well as the MD Anderson Cancer Center Support Grant CA 016672.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2021/10
Y1 - 2021/10
N2 - Purpose: This systematic review and meta-analysis aimed to determine whether physical function can predict mortality in patients with cancer. Methods: Literature searches were conducted in Web of Science, CINAHL, the Cochrane Library, ProQuest, PEDro, and PubMed for articles published before September 2020. Four review authors retrieved studies using predetermined eligibility criteria and conducted quality assessment and data extraction. Results: A total of 1356 titles and abstracts were screened; ultimately, 26 studies were determined to be suitable for meta-analysis. Grip strength was significantly associated with mortality risk in patients with cancer (hazard ratio [HR] = 1.15, P = 0.005). Gait speed was also associated with mortality risk (HR = 1.58, P = 0.0004). In grip strength and gait speed, the subgroup comprised of patients with cancer aged ≥ 80 years had a higher effect size than that of patients aged < 80 years. The short physical performance battery measurement was markedly associated with mortality risk, showing the largest effect size (HR = 2.37, P < 0.00001). The 6-min walking test distance was significantly associated with mortality risk (HR = 1.55, P = 0.001). The timed up and go test was significantly associated with mortality risk with a high effect size (HR = 2.66, P < 0.00001). Conclusion: This systematic review and meta-analysis demonstrated that physical function predicted mortality in patients with cancer. Furthermore, physical function outcomes in patients aged 80 years and above reflected a higher mortality.
AB - Purpose: This systematic review and meta-analysis aimed to determine whether physical function can predict mortality in patients with cancer. Methods: Literature searches were conducted in Web of Science, CINAHL, the Cochrane Library, ProQuest, PEDro, and PubMed for articles published before September 2020. Four review authors retrieved studies using predetermined eligibility criteria and conducted quality assessment and data extraction. Results: A total of 1356 titles and abstracts were screened; ultimately, 26 studies were determined to be suitable for meta-analysis. Grip strength was significantly associated with mortality risk in patients with cancer (hazard ratio [HR] = 1.15, P = 0.005). Gait speed was also associated with mortality risk (HR = 1.58, P = 0.0004). In grip strength and gait speed, the subgroup comprised of patients with cancer aged ≥ 80 years had a higher effect size than that of patients aged < 80 years. The short physical performance battery measurement was markedly associated with mortality risk, showing the largest effect size (HR = 2.37, P < 0.00001). The 6-min walking test distance was significantly associated with mortality risk (HR = 1.55, P = 0.001). The timed up and go test was significantly associated with mortality risk with a high effect size (HR = 2.66, P < 0.00001). Conclusion: This systematic review and meta-analysis demonstrated that physical function predicted mortality in patients with cancer. Furthermore, physical function outcomes in patients aged 80 years and above reflected a higher mortality.
KW - Cancer
KW - Mortality
KW - Oncology
KW - Physical function
KW - Rehabilitation
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U2 - 10.1007/s00520-021-06171-3
DO - 10.1007/s00520-021-06171-3
M3 - Review article
C2 - 33770257
AN - SCOPUS:85103348250
SN - 0941-4355
VL - 29
SP - 5623
EP - 5634
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 10
ER -