Physicochemical characterizations of amphiphilic block copolymers with different mws and micelles for development of anticancer drug nanocarriers

Jeong Min Yun, So Young Park, Eun Sung Lee, Yu Seok Youn, Ga Young Park, Chaemin Lim, Beom Jin Lee, Ho Taek Song, Young Taik Oh, Kyung Teak Oh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Biocompatible polymers have been of considerable interest in developing drug delivery systems (DDSs). However, physicochemical characterizations of the polymers and DDSs had been limited because of the difficulty in obtaining the same synthesized copolymers and achieving a similar drug loading ability with the differing properties of the drugs. Therefore, a correlational study of the relationships between copolymers and DDSs was required to estimate the properties of the DDSs and to develop optimal systems of delivery depending on the drug. In this study, we presented several relationship correlation equations of physicochemical properties and copolymers according to their molecular weights (MWs) using amphiphilic block copolymers composed of poly(L-lactide)-block-methoxy-poly(ethylene glycol) (PLA-b-mPEG). The PLA-b-mPEG was characterized by nuclear magnetic resonance and gel permeation chromatography, and the critical micelle concentration (CMC), sizes, and drug loading capacity (DLC) of the self-assembling micelles from the copolymers with different MWs were all measured. The increase in MW of the PLA led to a decrease in CMC and DLC with an increase of the particle sizes. The relationship between the MW of the PLA and the physicochemical properties of the micelles demonstrated a good correlation, which provides excellent information for the use in the development of tailor-made DDSs based on copolymers pursuing optimal particle size, DLC, CMC, and so on.

Original languageEnglish (US)
Pages (from-to)944-953
Number of pages10
JournalMacromolecular Research
Volume20
Issue number9
DOIs
StatePublished - Sep 1 2012

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Micelles
Block copolymers
Copolymers
Critical micelle concentration
Molecular weight
Pharmaceutical Preparations
Polyethylene glycols
Particle size
Polymers
Optimal systems
Gel permeation chromatography
Nuclear magnetic resonance
Drug Delivery Systems

Keywords

  • Amphiphilic block copolymer
  • Anticancer drugs
  • Correlation equation
  • Nano-sized drug carrier
  • PLA-b-mPEG
  • Polymeric micelles

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Physicochemical characterizations of amphiphilic block copolymers with different mws and micelles for development of anticancer drug nanocarriers. / Yun, Jeong Min; Park, So Young; Lee, Eun Sung; Youn, Yu Seok; Park, Ga Young; Lim, Chaemin; Lee, Beom Jin; Song, Ho Taek; Oh, Young Taik; Oh, Kyung Teak.

In: Macromolecular Research, Vol. 20, No. 9, 01.09.2012, p. 944-953.

Research output: Contribution to journalArticle

Yun, Jeong Min ; Park, So Young ; Lee, Eun Sung ; Youn, Yu Seok ; Park, Ga Young ; Lim, Chaemin ; Lee, Beom Jin ; Song, Ho Taek ; Oh, Young Taik ; Oh, Kyung Teak. / Physicochemical characterizations of amphiphilic block copolymers with different mws and micelles for development of anticancer drug nanocarriers. In: Macromolecular Research. 2012 ; Vol. 20, No. 9. pp. 944-953.
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