Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2

Mansa Gurjar; Kumarkrishna Raychaudhuri; Snehal Mahadik; Divya Reddy; Apurva Atak; Trupti Shetty; Kruthi Rao; Mansi S. Karkhanis; Prajakta Gosavi; Lalit Sehgal; Sanjay Gupta; Sorab N. Dalal

doi:10.1016/j.bbrc.2017.11.085

Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2

Mansa Gurjar
, Kumarkrishna Raychaudhuri
, Snehal Mahadik
, Divya Reddy
, Apurva Atak
, Trupti Shetty
, Kruthi Rao
, Mansi S. Karkhanis
, Prajakta Gosavi
, Lalit Sehgal
, Sanjay Gupta
, Sorab N. Dalal

Lymphoma-Myeloma

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Previous reports show that the desmosomal plaque protein plakophilin3 (PKP3) is essential for desmosome formation. Here, we report that PKP3 over-expression decreases calcium dependency for de novo desmosome formation and makes existing cell-cell adhesion junctions more resilient in low calcium medium due to an increase in desmocollin2 expression. PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins.

Original language	English (US)
Pages (from-to)	768-774
Number of pages	7
Journal	Biochemical and biophysical research communications
Volume	495
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2017.11.085
State	Published - Jan 1 2018

Keywords

Adhesion
Desmocollin 2
Desmosome
Plakophilin 3

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2017.11.085

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Gurjar, M., Raychaudhuri, K., Mahadik, S., Reddy, D., Atak, A., Shetty, T., Rao, K., Karkhanis, M. S., Gosavi, P., Sehgal, L., Gupta, S., & Dalal, S. N. (2018). Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2. Biochemical and biophysical research communications, 495(1), 768-774. https://doi.org/10.1016/j.bbrc.2017.11.085

Gurjar, M, Raychaudhuri, K, Mahadik, S, Reddy, D, Atak, A, Shetty, T, Rao, K, Karkhanis, MS, Gosavi, P, Sehgal, L, Gupta, S & Dalal, SN 2018, 'Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2', Biochemical and biophysical research communications, vol. 495, no. 1, pp. 768-774. https://doi.org/10.1016/j.bbrc.2017.11.085

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abstract = "Previous reports show that the desmosomal plaque protein plakophilin3 (PKP3) is essential for desmosome formation. Here, we report that PKP3 over-expression decreases calcium dependency for de novo desmosome formation and makes existing cell-cell adhesion junctions more resilient in low calcium medium due to an increase in desmocollin2 expression. PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins.",

keywords = "Adhesion, Desmocollin 2, Desmosome, Plakophilin 3",

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AU - Gurjar, Mansa

AU - Raychaudhuri, Kumarkrishna

AU - Mahadik, Snehal

AU - Reddy, Divya

AU - Atak, Apurva

AU - Shetty, Trupti

AU - Rao, Kruthi

AU - Karkhanis, Mansi S.

AU - Gosavi, Prajakta

AU - Sehgal, Lalit

AU - Gupta, Sanjay

AU - Dalal, Sorab N.

PY - 2018/1/1

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AB - Previous reports show that the desmosomal plaque protein plakophilin3 (PKP3) is essential for desmosome formation. Here, we report that PKP3 over-expression decreases calcium dependency for de novo desmosome formation and makes existing cell-cell adhesion junctions more resilient in low calcium medium due to an increase in desmocollin2 expression. PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins.

KW - Adhesion

KW - Desmocollin 2

KW - Desmosome

KW - Plakophilin 3

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IS - 1

ER -

Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2

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