Plasmonic fluorescent CdSe/Cu2S hybrid nanocrystals for multichannel imaging and cancer directed photo-thermal therapy

M. Sheikh Mohamed; Aby Cheruvathoor Poulose; Srivani Veeranarayanan; Rebecca Romero Aburto; Trevor Mitcham; Yuko Suzuki; Yasushi Sakamoto; Pulickel M. Ajayan; Richard R. Bouchard; Yasuhiko Yoshida; Toru Maekawa; D. Sakthi Kumar

doi:10.1039/c5nr05225d

Plasmonic fluorescent CdSe/Cu₂S hybrid nanocrystals for multichannel imaging and cancer directed photo-thermal therapy

M. Sheikh Mohamed, Aby Cheruvathoor Poulose, Srivani Veeranarayanan, Rebecca Romero Aburto, Trevor Mitcham, Yuko Suzuki, Yasushi Sakamoto, Pulickel M. Ajayan, Richard R. Bouchard, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar

Imaging Physics

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A simple, crude Jatropha curcas (JC) oil-based synthesis approach, devoid of any toxic phosphine and pyrophoric ligands, to produce size and shape tuned CdSe QDs and a further copper sulfide (Cu₂S) encasing is presented. The QDs exhibited excellent photoluminescent properties with narrow band gap emission. Furthermore, the Cu₂S shell rendered additional cytocompatibility and stability to the hybrid nanomaterial, which are major factors for translational and clinical applications of QDs. The nanocomposites were PEGylated and folate conjugated to augment their cytoamiability and enhance their specificity towards cancer cells. The nanohybrids possess potentials for visible, near infrared (NIR), photoacoustic (PA) and computed tomography (μCT) imaging. The diverse functionality of the composite was derived from the multi-channel imaging abilities and thermal competence on NIR laser irradiation to specifically actuate the photo-thermal ablation of brain cancer cells.

Original language	English (US)
Pages (from-to)	7876-7888
Number of pages	13
Journal	Nanoscale
Volume	8
Issue number	15
DOIs	https://doi.org/10.1039/c5nr05225d
State	Published - Apr 21 2016

ASJC Scopus subject areas

General Materials Science

MD Anderson CCSG core facilities

Research Animal Support Facility
Small Animal Imaging Facility

Access to Document

10.1039/c5nr05225d

Cite this

Sheikh Mohamed, M., Poulose, A. C., Veeranarayanan, S., Romero Aburto, R., Mitcham, T., Suzuki, Y., Sakamoto, Y., Ajayan, P. M., Bouchard, R. R., Yoshida, Y., Maekawa, T., & Sakthi Kumar, D. (2016). Plasmonic fluorescent CdSe/Cu₂S hybrid nanocrystals for multichannel imaging and cancer directed photo-thermal therapy. Nanoscale, 8(15), 7876-7888. https://doi.org/10.1039/c5nr05225d

Sheikh Mohamed, M, Poulose, AC, Veeranarayanan, S, Romero Aburto, R, Mitcham, T, Suzuki, Y, Sakamoto, Y, Ajayan, PM, Bouchard, RR, Yoshida, Y, Maekawa, T & Sakthi Kumar, D 2016, 'Plasmonic fluorescent CdSe/Cu₂S hybrid nanocrystals for multichannel imaging and cancer directed photo-thermal therapy', Nanoscale, vol. 8, no. 15, pp. 7876-7888. https://doi.org/10.1039/c5nr05225d

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abstract = "A simple, crude Jatropha curcas (JC) oil-based synthesis approach, devoid of any toxic phosphine and pyrophoric ligands, to produce size and shape tuned CdSe QDs and a further copper sulfide (Cu2S) encasing is presented. The QDs exhibited excellent photoluminescent properties with narrow band gap emission. Furthermore, the Cu2S shell rendered additional cytocompatibility and stability to the hybrid nanomaterial, which are major factors for translational and clinical applications of QDs. The nanocomposites were PEGylated and folate conjugated to augment their cytoamiability and enhance their specificity towards cancer cells. The nanohybrids possess potentials for visible, near infrared (NIR), photoacoustic (PA) and computed tomography (μCT) imaging. The diverse functionality of the composite was derived from the multi-channel imaging abilities and thermal competence on NIR laser irradiation to specifically actuate the photo-thermal ablation of brain cancer cells.",

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AU - Suzuki, Yuko

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