Pneumatosis Intestinalis Following Immune Checkpoint Inhibitor Therapy

Gabriel Sperling; Yang Lu; Malek Shatila; Krishnavathana Varatharajalu; Anam Khan; Yinghong Wang; Bryan Schneider

doi:10.1007/978-3-031-83533-9_20

Pneumatosis Intestinalis Following Immune Checkpoint Inhibitor Therapy

Gabriel Sperling
, Yang Lu
, Malek Shatila
, Krishnavathana Varatharajalu
, Anam Khan
, Yinghong Wang
, Bryan Schneider

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This is a patient with anaplastic thyroid cancer who had received two cycles of lenvatinib and pembrolizumab and subsequently developed acute pneumatosis intestinalis and immune-mediated colitis. He was treated with antibiotics, oxygen, and bowel rest with symptomatic remission and resolution on repeat imaging after 7 days. The patient unfortunately expired from cardiac arrest 3 weeks after hospital discharge.

Original language	English (US)
Title of host publication	Challenging Cases in Immunotherapy Related Organ Toxicities
Publisher	Springer Science+Business Media
Pages	143-148
Number of pages	6
ISBN (Electronic)	9783031835339
ISBN (Print)	9783031835322
DOIs	https://doi.org/10.1007/978-3-031-83533-9_20
State	Published - Jan 1 2025

Keywords

Colitis
Immune checkpoint inhibitor
Immunotherapy
Pneumatosis intestinalis

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-3-031-83533-9_20

Cite this

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abstract = "This is a patient with anaplastic thyroid cancer who had received two cycles of lenvatinib and pembrolizumab and subsequently developed acute pneumatosis intestinalis and immune-mediated colitis. He was treated with antibiotics, oxygen, and bowel rest with symptomatic remission and resolution on repeat imaging after 7 days. The patient unfortunately expired from cardiac arrest 3 weeks after hospital discharge.",

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AU - Sperling, Gabriel

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AU - Shatila, Malek

AU - Varatharajalu, Krishnavathana

AU - Khan, Anam

AU - Wang, Yinghong

AU - Schneider, Bryan

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AB - This is a patient with anaplastic thyroid cancer who had received two cycles of lenvatinib and pembrolizumab and subsequently developed acute pneumatosis intestinalis and immune-mediated colitis. He was treated with antibiotics, oxygen, and bowel rest with symptomatic remission and resolution on repeat imaging after 7 days. The patient unfortunately expired from cardiac arrest 3 weeks after hospital discharge.

KW - Colitis

KW - Immune checkpoint inhibitor

KW - Immunotherapy

KW - Pneumatosis intestinalis

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ER -

Pneumatosis Intestinalis Following Immune Checkpoint Inhibitor Therapy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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