Polymorphisms in genes coding for enzymes metabolizing smoking-derived substances and the risk of periodontitis

Jeong Sook Kim, Jong Y. Park, Won Yoon Chung, Min Ah Choi, Kyoo Sung Cho, Kwang Kyun Park

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objectives: Although the direct cause for periodontitis is oral bacterial infection, its progression depends upon genetic and environmental factors. Smoking, one of the environmental factors, is a risk factor for the development and severity of periodontitis. Therefore, individual susceptibility to periodontitis may be influenced by the polymorphisms of genes coding for enzymes metabolizing tobacco-derived substances. The object of this study is to investigate roles of genetic polymorphisms of these metabolizing enzymes in the risk for periodontitis. Material and Methods: We investigated three important enzymes: cytochrome P450 (CYP) 1A1, CYP2E1 and glutathione S-transferase (GST) M1, involved in the metabolic activation and detoxification of tobacco-derived substances. The prevalence of the polymorphisms of these genes was examined in 115 patients with periodontitis as well as in 126 control subjects. Results: Significantly increased risk for periodontitis was observed for subjects with the polymorphic CYP1A1 m2 allele (odds ratio (OR) = 2.3, 95% confidence interval (CI) = 1.2-4.4). A significant risk increase for periodontitis associated with the GSTM1 allele was observed (OR = 2.1, 95% CI = 1.3-3.6). However, no association was observed between the CYP2E1 Pst1 polymorphism and risk for periodontitis (OR = 1.3, 95% CI = 0.6-2.5). Conclusion: These results suggest that the GSTM1 and CYP1A1 polymorphisms may play an important role in risk for periodontitis.

Original languageEnglish (US)
Pages (from-to)959-964
Number of pages6
JournalJournal of Clinical Periodontology
Volume31
Issue number11
DOIs
StatePublished - Nov 1 2004

Fingerprint

Periodontitis
Smoking
Enzymes
Genes
Cytochrome P-450 CYP2E1
Cytochrome P-450 CYP1A1
Odds Ratio
Confidence Intervals
Tobacco
Alleles
Genetic Polymorphisms
Bacterial Infections
Cytochrome P-450 Enzyme System

Keywords

  • Cytochrome P450 1A1
  • Cytochrome P450 2E1
  • Glutathione S-transferase M1
  • Polymorphism, periodontitis

ASJC Scopus subject areas

  • Periodontics

Cite this

Polymorphisms in genes coding for enzymes metabolizing smoking-derived substances and the risk of periodontitis. / Kim, Jeong Sook; Park, Jong Y.; Chung, Won Yoon; Choi, Min Ah; Cho, Kyoo Sung; Park, Kwang Kyun.

In: Journal of Clinical Periodontology, Vol. 31, No. 11, 01.11.2004, p. 959-964.

Research output: Contribution to journalArticle

Kim, Jeong Sook ; Park, Jong Y. ; Chung, Won Yoon ; Choi, Min Ah ; Cho, Kyoo Sung ; Park, Kwang Kyun. / Polymorphisms in genes coding for enzymes metabolizing smoking-derived substances and the risk of periodontitis. In: Journal of Clinical Periodontology. 2004 ; Vol. 31, No. 11. pp. 959-964.
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abstract = "Objectives: Although the direct cause for periodontitis is oral bacterial infection, its progression depends upon genetic and environmental factors. Smoking, one of the environmental factors, is a risk factor for the development and severity of periodontitis. Therefore, individual susceptibility to periodontitis may be influenced by the polymorphisms of genes coding for enzymes metabolizing tobacco-derived substances. The object of this study is to investigate roles of genetic polymorphisms of these metabolizing enzymes in the risk for periodontitis. Material and Methods: We investigated three important enzymes: cytochrome P450 (CYP) 1A1, CYP2E1 and glutathione S-transferase (GST) M1, involved in the metabolic activation and detoxification of tobacco-derived substances. The prevalence of the polymorphisms of these genes was examined in 115 patients with periodontitis as well as in 126 control subjects. Results: Significantly increased risk for periodontitis was observed for subjects with the polymorphic CYP1A1 m2 allele (odds ratio (OR) = 2.3, 95{\%} confidence interval (CI) = 1.2-4.4). A significant risk increase for periodontitis associated with the GSTM1 allele was observed (OR = 2.1, 95{\%} CI = 1.3-3.6). However, no association was observed between the CYP2E1 Pst1 polymorphism and risk for periodontitis (OR = 1.3, 95{\%} CI = 0.6-2.5). Conclusion: These results suggest that the GSTM1 and CYP1A1 polymorphisms may play an important role in risk for periodontitis.",
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N2 - Objectives: Although the direct cause for periodontitis is oral bacterial infection, its progression depends upon genetic and environmental factors. Smoking, one of the environmental factors, is a risk factor for the development and severity of periodontitis. Therefore, individual susceptibility to periodontitis may be influenced by the polymorphisms of genes coding for enzymes metabolizing tobacco-derived substances. The object of this study is to investigate roles of genetic polymorphisms of these metabolizing enzymes in the risk for periodontitis. Material and Methods: We investigated three important enzymes: cytochrome P450 (CYP) 1A1, CYP2E1 and glutathione S-transferase (GST) M1, involved in the metabolic activation and detoxification of tobacco-derived substances. The prevalence of the polymorphisms of these genes was examined in 115 patients with periodontitis as well as in 126 control subjects. Results: Significantly increased risk for periodontitis was observed for subjects with the polymorphic CYP1A1 m2 allele (odds ratio (OR) = 2.3, 95% confidence interval (CI) = 1.2-4.4). A significant risk increase for periodontitis associated with the GSTM1 allele was observed (OR = 2.1, 95% CI = 1.3-3.6). However, no association was observed between the CYP2E1 Pst1 polymorphism and risk for periodontitis (OR = 1.3, 95% CI = 0.6-2.5). Conclusion: These results suggest that the GSTM1 and CYP1A1 polymorphisms may play an important role in risk for periodontitis.

AB - Objectives: Although the direct cause for periodontitis is oral bacterial infection, its progression depends upon genetic and environmental factors. Smoking, one of the environmental factors, is a risk factor for the development and severity of periodontitis. Therefore, individual susceptibility to periodontitis may be influenced by the polymorphisms of genes coding for enzymes metabolizing tobacco-derived substances. The object of this study is to investigate roles of genetic polymorphisms of these metabolizing enzymes in the risk for periodontitis. Material and Methods: We investigated three important enzymes: cytochrome P450 (CYP) 1A1, CYP2E1 and glutathione S-transferase (GST) M1, involved in the metabolic activation and detoxification of tobacco-derived substances. The prevalence of the polymorphisms of these genes was examined in 115 patients with periodontitis as well as in 126 control subjects. Results: Significantly increased risk for periodontitis was observed for subjects with the polymorphic CYP1A1 m2 allele (odds ratio (OR) = 2.3, 95% confidence interval (CI) = 1.2-4.4). A significant risk increase for periodontitis associated with the GSTM1 allele was observed (OR = 2.1, 95% CI = 1.3-3.6). However, no association was observed between the CYP2E1 Pst1 polymorphism and risk for periodontitis (OR = 1.3, 95% CI = 0.6-2.5). Conclusion: These results suggest that the GSTM1 and CYP1A1 polymorphisms may play an important role in risk for periodontitis.

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