Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors

Hui Chen; Cheddhi Thomas; Felipe Andres Munoz; Sanda Alexandrescu; Craig M. Horbinski; Adriana Olar; Declan McGuone; Sandra Camelo-Piragua; Lu Wang; Elena Pentsova; Joanna Phillips; Kenneth Aldape; Wen Chen; A. John Iafrate; Andrew S. Chi; David Zagzag; John G. Golfinos; Dimitris G. Placantonakis; Marc Rosenblum; Pamela Ohman-Strickland; Meera Hameed; Matija Snuderl

doi:10.1093/neuonc/noz098

Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors

Hui Chen, Cheddhi Thomas, Felipe Andres Munoz, Sanda Alexandrescu, Craig M. Horbinski, Adriana Olar, Declan McGuone, Sandra Camelo-Piragua, Lu Wang, Elena Pentsova, Joanna Phillips, Kenneth Aldape, Wen Chen, A. John Iafrate, Andrew S. Chi, David Zagzag, John G. Golfinos, Dimitris G. Placantonakis, Marc Rosenblum, Pamela Ohman-StricklandMeera Hameed, Matija Snuderl

Pathology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Chromosomal instability is associated with earlier progression in isocitrate dehydrogenase (IDH)-mutated astrocytomas. Here we evaluated the prognostic significance of polysomy in gliomas tested for 1p/19q status. Methods: We analyzed 412 histologic oligodendroglial tumors with use of 1p/19q testing at 8 institutions from 1996 to 2013; fluorescence in situ hybridization (FISH) for 1p/19q was performed. Polysomy was defined as more than two 1q and 19p signals in cells. Tumors were divided into groups on the basis of their 1p/19q status and polysomy and were compared for progression-free survival (PFS) and overall survival (OS). Results: In our cohort, 333 tumors (81%) had 1p/19q loss; of these, 195 (59%) had concurrent polysomy and 138 (41%) lacked polysomy, 79 (19%) had 1p/19q maintenance; of these, 30 (38%) had concurrent polysomy and 49 (62%) lacked polysomy. In agreement with prior studies, the group with 1p/19q loss had significantly better PFS and OS than did the group with 1p/19q maintenance (P < 0.0001 each). Patients with 1p/19q loss and polysomy showed significantly shorter PFS survival than patients with 1p/19q codeletion only (P < 0.0001), but longer PFS and OS than patients with 1p/19q maintenance (P < 0.01 and P < 0.0001). There was no difference in survival between tumors with >30% polysomic cells and those with <30% polysomic cells. Polysomy had no prognostic significance on PFS or OS in patients with 1p/19q maintenance. Conclusions: The presence of polysomy in oligodendroglial tumors with codeletion of 1p/19q predicts early recurrence and short survival in patients with 1p/19q codeleted tumors.

Original language	English (US)
Pages (from-to)	1164-1174
Number of pages	11
Journal	Neuro-oncology
Volume	21
Issue number	9
DOIs	https://doi.org/10.1093/neuonc/noz098
State	Published - Sep 6 2019

Keywords

1p/19q codeletion
Glioma
Oligodendroglioma
Polysomy

ASJC Scopus subject areas

Oncology
Clinical Neurology
Cancer Research

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10.1093/neuonc/noz098

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Chen, H., Thomas, C., Munoz, F. A., Alexandrescu, S., Horbinski, C. M., Olar, A., McGuone, D., Camelo-Piragua, S., Wang, L., Pentsova, E., Phillips, J., Aldape, K., Chen, W., Iafrate, A. J., Chi, A. S., Zagzag, D., Golfinos, J. G., Placantonakis, D. G., Rosenblum, M., ... Snuderl, M. (2019). Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors. Neuro-oncology, 21(9), 1164-1174. https://doi.org/10.1093/neuonc/noz098

Chen, H, Thomas, C, Munoz, FA, Alexandrescu, S, Horbinski, CM, Olar, A, McGuone, D, Camelo-Piragua, S, Wang, L, Pentsova, E, Phillips, J, Aldape, K, Chen, W, Iafrate, AJ, Chi, AS, Zagzag, D, Golfinos, JG, Placantonakis, DG, Rosenblum, M, Ohman-Strickland, P, Hameed, M & Snuderl, M 2019, 'Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors', Neuro-oncology, vol. 21, no. 9, pp. 1164-1174. https://doi.org/10.1093/neuonc/noz098

@article{cfbbe1d050dc4d1a808144d1b64b38b1,

title = "Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors",

abstract = "Background: Chromosomal instability is associated with earlier progression in isocitrate dehydrogenase (IDH)-mutated astrocytomas. Here we evaluated the prognostic significance of polysomy in gliomas tested for 1p/19q status. Methods: We analyzed 412 histologic oligodendroglial tumors with use of 1p/19q testing at 8 institutions from 1996 to 2013; fluorescence in situ hybridization (FISH) for 1p/19q was performed. Polysomy was defined as more than two 1q and 19p signals in cells. Tumors were divided into groups on the basis of their 1p/19q status and polysomy and were compared for progression-free survival (PFS) and overall survival (OS). Results: In our cohort, 333 tumors (81%) had 1p/19q loss; of these, 195 (59%) had concurrent polysomy and 138 (41%) lacked polysomy, 79 (19%) had 1p/19q maintenance; of these, 30 (38%) had concurrent polysomy and 49 (62%) lacked polysomy. In agreement with prior studies, the group with 1p/19q loss had significantly better PFS and OS than did the group with 1p/19q maintenance (P < 0.0001 each). Patients with 1p/19q loss and polysomy showed significantly shorter PFS survival than patients with 1p/19q codeletion only (P < 0.0001), but longer PFS and OS than patients with 1p/19q maintenance (P < 0.01 and P < 0.0001). There was no difference in survival between tumors with >30% polysomic cells and those with <30% polysomic cells. Polysomy had no prognostic significance on PFS or OS in patients with 1p/19q maintenance. Conclusions: The presence of polysomy in oligodendroglial tumors with codeletion of 1p/19q predicts early recurrence and short survival in patients with 1p/19q codeleted tumors.",

keywords = "1p/19q codeletion, Glioma, Oligodendroglioma, Polysomy",

author = "Hui Chen and Cheddhi Thomas and Munoz, {Felipe Andres} and Sanda Alexandrescu and Horbinski, {Craig M.} and Adriana Olar and Declan McGuone and Sandra Camelo-Piragua and Lu Wang and Elena Pentsova and Joanna Phillips and Kenneth Aldape and Wen Chen and Iafrate, {A. John} and Chi, {Andrew S.} and David Zagzag and Golfinos, {John G.} and Placantonakis, {Dimitris G.} and Marc Rosenblum and Pamela Ohman-Strickland and Meera Hameed and Matija Snuderl",

year = "2019",

month = sep,

day = "6",

doi = "10.1093/neuonc/noz098",

language = "English (US)",

volume = "21",

pages = "1164--1174",

journal = "Neuro-oncology",

issn = "1522-8517",

publisher = "Oxford University Press",

number = "9",

}

TY - JOUR

T1 - Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors

AU - Chen, Hui

AU - Thomas, Cheddhi

AU - Munoz, Felipe Andres

AU - Alexandrescu, Sanda

AU - Horbinski, Craig M.

AU - Olar, Adriana

AU - McGuone, Declan

AU - Camelo-Piragua, Sandra

AU - Wang, Lu

AU - Pentsova, Elena

AU - Phillips, Joanna

AU - Aldape, Kenneth

AU - Chen, Wen

AU - Iafrate, A. John

AU - Chi, Andrew S.

AU - Zagzag, David

AU - Golfinos, John G.

AU - Placantonakis, Dimitris G.

AU - Rosenblum, Marc

AU - Ohman-Strickland, Pamela

AU - Hameed, Meera

AU - Snuderl, Matija

PY - 2019/9/6

Y1 - 2019/9/6

N2 - Background: Chromosomal instability is associated with earlier progression in isocitrate dehydrogenase (IDH)-mutated astrocytomas. Here we evaluated the prognostic significance of polysomy in gliomas tested for 1p/19q status. Methods: We analyzed 412 histologic oligodendroglial tumors with use of 1p/19q testing at 8 institutions from 1996 to 2013; fluorescence in situ hybridization (FISH) for 1p/19q was performed. Polysomy was defined as more than two 1q and 19p signals in cells. Tumors were divided into groups on the basis of their 1p/19q status and polysomy and were compared for progression-free survival (PFS) and overall survival (OS). Results: In our cohort, 333 tumors (81%) had 1p/19q loss; of these, 195 (59%) had concurrent polysomy and 138 (41%) lacked polysomy, 79 (19%) had 1p/19q maintenance; of these, 30 (38%) had concurrent polysomy and 49 (62%) lacked polysomy. In agreement with prior studies, the group with 1p/19q loss had significantly better PFS and OS than did the group with 1p/19q maintenance (P < 0.0001 each). Patients with 1p/19q loss and polysomy showed significantly shorter PFS survival than patients with 1p/19q codeletion only (P < 0.0001), but longer PFS and OS than patients with 1p/19q maintenance (P < 0.01 and P < 0.0001). There was no difference in survival between tumors with >30% polysomic cells and those with <30% polysomic cells. Polysomy had no prognostic significance on PFS or OS in patients with 1p/19q maintenance. Conclusions: The presence of polysomy in oligodendroglial tumors with codeletion of 1p/19q predicts early recurrence and short survival in patients with 1p/19q codeleted tumors.

AB - Background: Chromosomal instability is associated with earlier progression in isocitrate dehydrogenase (IDH)-mutated astrocytomas. Here we evaluated the prognostic significance of polysomy in gliomas tested for 1p/19q status. Methods: We analyzed 412 histologic oligodendroglial tumors with use of 1p/19q testing at 8 institutions from 1996 to 2013; fluorescence in situ hybridization (FISH) for 1p/19q was performed. Polysomy was defined as more than two 1q and 19p signals in cells. Tumors were divided into groups on the basis of their 1p/19q status and polysomy and were compared for progression-free survival (PFS) and overall survival (OS). Results: In our cohort, 333 tumors (81%) had 1p/19q loss; of these, 195 (59%) had concurrent polysomy and 138 (41%) lacked polysomy, 79 (19%) had 1p/19q maintenance; of these, 30 (38%) had concurrent polysomy and 49 (62%) lacked polysomy. In agreement with prior studies, the group with 1p/19q loss had significantly better PFS and OS than did the group with 1p/19q maintenance (P < 0.0001 each). Patients with 1p/19q loss and polysomy showed significantly shorter PFS survival than patients with 1p/19q codeletion only (P < 0.0001), but longer PFS and OS than patients with 1p/19q maintenance (P < 0.01 and P < 0.0001). There was no difference in survival between tumors with >30% polysomic cells and those with <30% polysomic cells. Polysomy had no prognostic significance on PFS or OS in patients with 1p/19q maintenance. Conclusions: The presence of polysomy in oligodendroglial tumors with codeletion of 1p/19q predicts early recurrence and short survival in patients with 1p/19q codeleted tumors.

KW - 1p/19q codeletion

KW - Glioma

KW - Oligodendroglioma

KW - Polysomy

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DO - 10.1093/neuonc/noz098

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AN - SCOPUS:85073443859

SN - 1522-8517

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JO - Neuro-oncology

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ER -

Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors

Abstract

Keywords

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