Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis

Tomo o. Ishikawa; Indracanti Prem Kumar; Hidevaldo B. Machado; Koon Pong Wong; Donna Kusewitt; Sung Cheng Huang; Susan M. Fischer; Harvey R. Herschman

doi:10.1016/j.molonc.2010.01.005

Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis

Tomo o. Ishikawa
, Indracanti Prem Kumar
, Hidevaldo B. Machado
, Koon Pong Wong
, Donna Kusewitt
, Sung Cheng Huang
, Susan M. Fischer
, Harvey R. Herschman

Epigenetics & Molecular Carcinogenesis

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Many tumor cells have elevated rates of glucose uptake that can be measured quantitatively, noninvasively and repeatedly by positron emission tomography (PET) with 2-deoxy-2-[¹⁸F]-fluoro-D-glucose (¹⁸F-FDG). Clinical imaging with ¹⁸F-FDG PET has been used for detection and staging of primary and metastatic tumors. High-resolution microPET scanning and murine cancer models make it possible to analyze longitudinally glucose metabolism during the appearance, development and progression of individual experimental tumors. In this study, we used ¹⁸F-FDG microPET and micro computerized tomography (microCT) to investigate glucose uptake in the DMBA/TPA chemically-induced multistage mouse skin carcinogenesis model. ¹⁸F-FDG uptake is significantly higher in all papillomas than in surrounding skin. Elevated ¹⁸F-FDG uptake is observed when tumors can be identified morphologically, but not before. Although ¹⁸F-FDG uptake is high in all fully invasive, malignant skin squamous cell carcinomas, uptake in papillomas and microinvasive malignant squamous cell carcinomas is variable and does not exhibit any correlation with tumor stage.

Original language	English (US)
Pages (from-to)	119-125
Number of pages	7
Journal	Molecular oncology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/j.molonc.2010.01.005
State	Published - Apr 2010

Keywords

Fluorodeoxyglucose
Glucose metabolism
Molecular imaging
PET
Skin cancer

ASJC Scopus subject areas

Molecular Medicine
Genetics
Oncology
Cancer Research

MD Anderson CCSG core facilities

Research Animal Support Facility

Access to Document

10.1016/j.molonc.2010.01.005

Cite this

@article{11fa11114015469ba4de1baa5822dddf,

title = "Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis",

abstract = "Many tumor cells have elevated rates of glucose uptake that can be measured quantitatively, noninvasively and repeatedly by positron emission tomography (PET) with 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG). Clinical imaging with 18F-FDG PET has been used for detection and staging of primary and metastatic tumors. High-resolution microPET scanning and murine cancer models make it possible to analyze longitudinally glucose metabolism during the appearance, development and progression of individual experimental tumors. In this study, we used 18F-FDG microPET and micro computerized tomography (microCT) to investigate glucose uptake in the DMBA/TPA chemically-induced multistage mouse skin carcinogenesis model. 18F-FDG uptake is significantly higher in all papillomas than in surrounding skin. Elevated 18F-FDG uptake is observed when tumors can be identified morphologically, but not before. Although 18F-FDG uptake is high in all fully invasive, malignant skin squamous cell carcinomas, uptake in papillomas and microinvasive malignant squamous cell carcinomas is variable and does not exhibit any correlation with tumor stage.",

keywords = "Fluorodeoxyglucose, Glucose metabolism, Molecular imaging, PET, Skin cancer",

author = "Ishikawa, \{Tomo o.\} and Kumar, \{Indracanti Prem\} and Machado, \{Hidevaldo B.\} and Wong, \{Koon Pong\} and Donna Kusewitt and Huang, \{Sung Cheng\} and Fischer, \{Susan M.\} and Herschman, \{Harvey R.\}",

note = "Funding Information: We thank Arthur Catapang and the members of the UCLA Small Animal Imaging Shared Resource for technical assistance. These studies were supported by NIH awards R01 CA084572, R01 CA 123055 and P50 CA086306 to HRH, and CA100140 to SF. IPK was supported by an overseas associateship from the Department of Biotechnology, Government of India.",

year = "2010",

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doi = "10.1016/j.molonc.2010.01.005",

language = "English (US)",

volume = "4",

pages = "119--125",

journal = "Molecular oncology",

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publisher = "John Wiley and Sons Ltd",

number = "2",

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AU - Ishikawa, Tomo o.

AU - Kumar, Indracanti Prem

AU - Machado, Hidevaldo B.

AU - Wong, Koon Pong

AU - Kusewitt, Donna

AU - Huang, Sung Cheng

AU - Fischer, Susan M.

AU - Herschman, Harvey R.

N1 - Funding Information: We thank Arthur Catapang and the members of the UCLA Small Animal Imaging Shared Resource for technical assistance. These studies were supported by NIH awards R01 CA084572, R01 CA 123055 and P50 CA086306 to HRH, and CA100140 to SF. IPK was supported by an overseas associateship from the Department of Biotechnology, Government of India.

PY - 2010/4

Y1 - 2010/4

N2 - Many tumor cells have elevated rates of glucose uptake that can be measured quantitatively, noninvasively and repeatedly by positron emission tomography (PET) with 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG). Clinical imaging with 18F-FDG PET has been used for detection and staging of primary and metastatic tumors. High-resolution microPET scanning and murine cancer models make it possible to analyze longitudinally glucose metabolism during the appearance, development and progression of individual experimental tumors. In this study, we used 18F-FDG microPET and micro computerized tomography (microCT) to investigate glucose uptake in the DMBA/TPA chemically-induced multistage mouse skin carcinogenesis model. 18F-FDG uptake is significantly higher in all papillomas than in surrounding skin. Elevated 18F-FDG uptake is observed when tumors can be identified morphologically, but not before. Although 18F-FDG uptake is high in all fully invasive, malignant skin squamous cell carcinomas, uptake in papillomas and microinvasive malignant squamous cell carcinomas is variable and does not exhibit any correlation with tumor stage.

AB - Many tumor cells have elevated rates of glucose uptake that can be measured quantitatively, noninvasively and repeatedly by positron emission tomography (PET) with 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG). Clinical imaging with 18F-FDG PET has been used for detection and staging of primary and metastatic tumors. High-resolution microPET scanning and murine cancer models make it possible to analyze longitudinally glucose metabolism during the appearance, development and progression of individual experimental tumors. In this study, we used 18F-FDG microPET and micro computerized tomography (microCT) to investigate glucose uptake in the DMBA/TPA chemically-induced multistage mouse skin carcinogenesis model. 18F-FDG uptake is significantly higher in all papillomas than in surrounding skin. Elevated 18F-FDG uptake is observed when tumors can be identified morphologically, but not before. Although 18F-FDG uptake is high in all fully invasive, malignant skin squamous cell carcinomas, uptake in papillomas and microinvasive malignant squamous cell carcinomas is variable and does not exhibit any correlation with tumor stage.

KW - Fluorodeoxyglucose

KW - Glucose metabolism

KW - Molecular imaging

KW - PET

KW - Skin cancer

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Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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