TY - JOUR
T1 - Post-radiation vascular lesions of the breast
AU - Ronen, Shira
AU - Ivan, Doina
AU - Torres-Cabala, Carlos A.
AU - Curry, Jonathan L.
AU - Tetzlaff, Michael
AU - Aung, Phyu P.
AU - Nagarajan, Priyadharsini
AU - Suster, Saul
AU - Prieto, Victor G.
N1 - Publisher Copyright:
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2019/1
Y1 - 2019/1
N2 - Post-radiation vascular lesions are a rare complication most commonly seen in patients previously treated for breast cancer. The main two entities include angiosarcoma (AS), which are malignant tumors that have a poor prognosis, and atypical vascular lesions (AVL), which typically behave in a benign manner and only rarely progress to angiosarcoma. The overall incidence of these lesions is low, but it appears to be increasing. Histopathologic distinction of AVL and AS is essential due to different clinical outcomes and treatment. However, due to the occasional existence of overlapping clinical and histopathologic features, it may be sometimes difficult to render a definite diagnosis, particularly in small biopsies. Ancillary techniques are, in general, of little help for separating the borderland cases but, in some instances, immunohistochemical study (IHC) for Ki67 and IHC or fluorescence in situ hybridization analysis for MYC may help in the diagnosis of angiosarcoma. Herein we discuss the clinical characteristics, histopathologic features, management strategies, and outcome of these lesions, with special emphasis on their differential diagnosis.
AB - Post-radiation vascular lesions are a rare complication most commonly seen in patients previously treated for breast cancer. The main two entities include angiosarcoma (AS), which are malignant tumors that have a poor prognosis, and atypical vascular lesions (AVL), which typically behave in a benign manner and only rarely progress to angiosarcoma. The overall incidence of these lesions is low, but it appears to be increasing. Histopathologic distinction of AVL and AS is essential due to different clinical outcomes and treatment. However, due to the occasional existence of overlapping clinical and histopathologic features, it may be sometimes difficult to render a definite diagnosis, particularly in small biopsies. Ancillary techniques are, in general, of little help for separating the borderland cases but, in some instances, immunohistochemical study (IHC) for Ki67 and IHC or fluorescence in situ hybridization analysis for MYC may help in the diagnosis of angiosarcoma. Herein we discuss the clinical characteristics, histopathologic features, management strategies, and outcome of these lesions, with special emphasis on their differential diagnosis.
KW - angiosarcoma
KW - atypical vascular lesion
KW - breast
KW - post-radiation vascular lesions
KW - skin
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U2 - 10.1111/cup.13363
DO - 10.1111/cup.13363
M3 - Review article
C2 - 30251277
AN - SCOPUS:85055930255
SN - 0303-6987
VL - 46
SP - 52
EP - 58
JO - Journal of cutaneous pathology
JF - Journal of cutaneous pathology
IS - 1
ER -