Post-translational modifications in signal integration

Yonathan Lissanu Deribe; Tony Pawson; Ivan Dikic

doi:10.1038/nsmb.1842

Post-translational modifications in signal integration

Yonathan Lissanu Deribe, Tony Pawson, Ivan Dikic

Research output: Contribution to journal › Review article › peer-review

603 Scopus citations

Abstract

Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations in the cellular microenvironment. Here we review the common principles of post-translational modifications and their importance in signal integration underlying epidermal growth factor receptor signaling and endocytosis, DNA-damage responses and immunity.

Original language	English (US)
Pages (from-to)	666-672
Number of pages	7
Journal	Nature Structural and Molecular Biology
Volume	17
Issue number	6
DOIs	https://doi.org/10.1038/nsmb.1842
State	Published - Jun 2010
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1038/nsmb.1842

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abstract = "Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations in the cellular microenvironment. Here we review the common principles of post-translational modifications and their importance in signal integration underlying epidermal growth factor receptor signaling and endocytosis, DNA-damage responses and immunity.",

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Post-translational modifications in signal integration

Abstract

ASJC Scopus subject areas

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