Postoperative pancreatic fistula after distal pancreatectomy for non-pancreas retroperitoneal tumor resection

Emily Z. Keung, Elliot A. Asare, Yi Ju Chiang, Laura R. Prakash, Nikita Rajkot, Keila E. Torres, Kelly K. Hunt, Barry W. Feig, Janice N. Cormier, Christina L. Roland, Matthew H.G. Katz, Jeffrey E. Lee, Ching Wei D. Tzeng

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Introduction: Short-term outcomes after distal pancreatectomy (DP) for retroperitoneal (RP) tumors are unknown. We sought to identify rates of postoperative pancreatic fistula (POPF) and morbidity after en bloc DP with RP tumor resection. Methods: A retrospective review of 43 patients who underwent DP with RP tumor resection (1/2011–12/2017) was performed. Results: Seventeen patients had RP sarcoma, 12 renal cell carcinoma, 11 gastrointestinal stromal tumor, and 3 adrenocortical carcinoma. Grade III-IV complications occurred in 7 patients. Grade B POPF occurred in 14 patients, grade C POPF in none, and biochemical leak in 6. Of 22 patients who developed radiographically evident peri-pancreatic fluid collections, 7 required percutaneous drainage. The 90-day readmission rate was 33%. Conclusions: DP with RP tumor resection is associated with high rates of clinically relevant POPF compared to historical results for DP for primary pancreatic tumors. Multi-center studies to identify targetable predictors and risk mitigation strategies for POPF in this rare high-risk population are needed.

Original languageEnglish (US)
Pages (from-to)140-146
Number of pages7
JournalAmerican Journal of Surgery
Volume220
Issue number1
DOIs
StatePublished - Jul 2020

Keywords

  • Fistula
  • Leak
  • Pancreatectomy
  • Postoperative pancreatic fistula
  • Retroperitoneal
  • Staple
  • Suture

ASJC Scopus subject areas

  • Surgery

MD Anderson CCSG core facilities

  • Clinical Trials Office

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