Abstract
Background: The zebrafish is a powerful vertebrate model organism for large scale genetic and chemical screens. Objective: With the rapid development of cancer modeling in zebrafish, great opportunities exist for chemical screens to find anticancer agents. Methods: Using embryos, pathway screens can be designed based on our knowledge of cancer biology. Anticancer chemical screens using tumor bearing adult zebrafish facilitate preclinical testing. Conclusion: Current developments in improving cancer models and automated imaging technology have the potential of finding novel compounds that disrupt tumor biology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1451-1460 |
| Number of pages | 10 |
| Journal | Expert Opinion on Drug Discovery |
| Volume | 3 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2008 |
| Externally published | Yes |
Keywords
- Cancer model
- Chemical screen
- Zebrafish
ASJC Scopus subject areas
- Drug Discovery