Predicting liver-related events using transient elastography in chronic hepatitis C patients with sustained virological response

Hye Won Lee, Young Eun Chon, Seung Up Kim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kyu Sik Jung, Young Nyun Park, Kwang Hyub Han

    Research output: Contribution to journalArticle

    15 Scopus citations

    Abstract

    Background/Aims: Few studies have investigated prognostic factors for the development of liver-related events (LREs) in patients with chronic hepatitis C (CHC) who achieve sustained virological response (SVR). Methods: We analyzed 190 patients with CHC who achieved SVR after treatment with pegylated interferon (peg-IFN) plus ribavirin. LREs were defined as any complications related to cirrhosis, hepatocellular carcinoma (HCC), or liver-related mortality. Results: The mean age was 54.1 years, and 84 of the patients (44.2%) were male. The mean liver stiffness (LS) value at SVR was 7.1±5.4 kPa. During the follow-up period (median, 43.0 months), LREs occurred in 10 patients (5.3%; HCC in eight patients, ascites in one patient, and liver-related mortality in one patient). By multivariate Cox regression analysis, age, a-fetoprotein level, and LS value were independent predictors for LRE development (all p < 0.05). Patients with LS values ≥7.0 kPa had a greater risk (hazard ratio, 9.472; 95% confidence interval, 1.018 to 88.126; p=0.048) for LRE development compared to those with LS values < 7.0 kPa. Conclusions: The LS value at SVR is useful for predicting LRE development in CHC patients who achieve SVR after treatment with peg-IFN plus ribavirin. Thus, LRE surveillance strategies might be optimized according to the LS values at SVR, even with complete viral eradication.

    Original languageEnglish (US)
    Pages (from-to)429-436
    Number of pages8
    JournalGut and Liver
    Volume10
    Issue number3
    DOIs
    StatePublished - Jan 1 2016

      Fingerprint

    Keywords

    • Carcinoma
    • Chronic
    • Hepatitis C
    • Hepatocellular
    • Liver stiffness
    • Sustained virological response
    • Transient elastography

    ASJC Scopus subject areas

    • Hepatology
    • Gastroenterology

    Cite this

    Lee, H. W., Chon, Y. E., Kim, S. U., Kim, B. K., Park, J. Y., Kim, D. Y., Ahn, S. H., Jung, K. S., Park, Y. N., & Han, K. H. (2016). Predicting liver-related events using transient elastography in chronic hepatitis C patients with sustained virological response. Gut and Liver, 10(3), 429-436. https://doi.org/10.5009/gnl15021